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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 39 - 44 (6page)
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This study aimed to investigate whether neurotransmitter receptors in the nervous system were also expressed in oral keratinocytes. Expressions of various neurotransmitter receptor genes in immortalized mouse oral keratinocyte (IMOK) cells were examined by reverse transcriptase polymerase chain reaction. IMOK cells expressed calcitonin gene-related peptide (CGRP) receptor subunit genes Ramp1 and Ramp3 and glutamate receptor subunit genes Grina , Gria3 , Grin1 , Grin2a , and Grin2d . Moreover, IMOK cells expressed Adrb2 and Chrna5 that encode beta 2 adrenergic receptor and cholinergic receptor nicotinic alpha 5 for sympathetic and parasympathetic neurotransmitters, respectively. The expression of Bdkrb1 and Ptger4 , which encode receptors for bradykinin and prostaglandin E2 involved in inflammatory responses, was also observed at low levels. Expressions of Ramp1 and Grina in the mouse gingival epithelium were also confirmed by immunohistochemistry. When the function of neurotransmitter receptors expressed on IMOK cells was tested by intracellular calcium response, CGRP, glutamate, and cholinergic receptors did not respond to their agonists, but the bradykinin receptor responded to bradykinin. Collectively, oral keratinocytes express several neurotransmitter receptors, suggesting the potential regulation of oral epithelial homeostasis by the nervous system.
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참고문헌 (16)
참고문헌 신청
Vander AJ / 1994 / Human physiology: the mechanisms of body function / McGrawHill
Wang D / 2009 / Reticular formation and spinal cord injury / Spinal Cord 47:204~212
Lodish HF / 2008 / Molecular cell biology / WH Freeman :1055~1104
Godinho-Silva C / 2019 / Neuroimmune cell units : a new paradigm in physiology / Annu Rev Immunol 37:19~46
Prado C / 2012 / Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity / J Immunol 188:3062~3070
Wang D / 2009 / Reticular formation and spinal cord injury / Spinal Cord 47:204~212
Lodish HF / 2008 / Molecular cell biology / WH Freeman :1055~1104
Godinho-Silva C / 2019 / Neuroimmune cell units : a new paradigm in physiology / Annu Rev Immunol 37:19~46
Prado C / 2012 / Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity / J Immunol 188:3062~3070
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