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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 131 - 143 (13page)
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초록· 키워드
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CD8<SUP>+</SUP> T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8<SUP>+</SUP> T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8<SUP>+</SUP> T cells have been found to express activating or inhibitory NK receptors. CD8<SUP>+</SUP> T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8<SUP>+</SUP> T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8<SUP>+</SUP> T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations.
목차
ABSTRACT
INTRODUCTION
CD8+ T CELLS EXPRESSING CD56
CD8+ T CELLS EXPRESSING KIRs
CD8+ T CELLS EXPRESSING NKG2A
CD8+ T CELLS EXPRESSING NKG2C
CONCLUSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2023-517-000427258