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논문 기본 정보

자료유형
학술저널
저자정보
June-Young Koh (Korea Advanced Institute of Science and Technology (KAIST)) Dong-Uk Kim (Korea Advanced Institute of Science and Technology (KAIST)) Bae-Hyeon Moon (Korea Advanced Institute of Science and Technology (KAIST)) Eui-Cheol Shin (Korea Advanced Institute of Science and Technology (KAIST))
저널정보
대한면역학회 Immune Network Immune Network Vol.23 No.1
발행연도
2023.2
수록면
131 - 143 (13page)

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초록· 키워드

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CD8<SUP>+</SUP> T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8<SUP>+</SUP> T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8<SUP>+</SUP> T cells have been found to express activating or inhibitory NK receptors. CD8<SUP>+</SUP> T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8<SUP>+</SUP> T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8<SUP>+</SUP> T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations.

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ABSTRACT
INTRODUCTION
CD8+ T CELLS EXPRESSING CD56
CD8+ T CELLS EXPRESSING KIRs
CD8+ T CELLS EXPRESSING NKG2A
CD8+ T CELLS EXPRESSING NKG2C
CONCLUSION
REFERENCES

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