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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 226 - 233 (8page)
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ObjectiveThis study aimed to investigate the prognosis of patients with intermediate-risk cervical cancer and to evaluate thenecessity of adjuvant therapy. MethodsWe conducted a retrospective chart review of patients with stage IB?II cervical cancer who underwent type III radicalhysterectomy with pelvic lymphadenectomy between 2008 and 2017. In our institution, radical hysterectomy isperformed as an open surgery and not as a minimally invasive surgery, and adjuvant therapy is not administeredto patients with intermediate-risk cervical cancer. The intermediate-risk group included patients with 2 or more ofthe following factors: tumor size >4 cm, stromal invasion >1/2, and lymphovascular stromal invasion. Intermediateriskpatients with squamous cell carcinoma were included in the I-SCC group, whereas those with endocervicaladenocarcinoma, usual type, or adenosquamous carcinoma were included in the I-Adeno group. ResultsThere were 34 and 18 patients in the I-SCC and I-Adeno groups, respectively. The 5-year recurrence-free survival(RFS) and overall survival rates in the I-SCC group were 90.5% (95% confidence interval [CI], 85.3?95.7%) and 100%(95% CI, 100%), respectively, whereas those in the I-Adeno group were 54.9% (95% CI, 42.0?67.9%) and 76.1%(95% CI, 63.7?88.4%), respectively. Multivariate analysis revealed that endocervical adenocarcinoma, usual type, oradenosquamous carcinoma, and tumor size >4 cm had worse RFS. ConclusionThe I-SCC group had good prognosis without adjuvant therapy; therefore, adjuvant therapy may be omitted in thesepatients. In contrast, the I-Adeno group had poor prognosis without adjuvant therapy; therefore, adjuvant therapyshould be considered in their treatment.
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참고문헌 (17)
참고문헌 신청
Sedlis A / 1999 / A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy : a Gynecologic Oncology Group study / Gynecol Oncol 73:177~183
Rotman M / 2006 / A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features : follow-up of a gynecologic oncology group study / Int J Radiat Oncol Biol Phys 65:169~176
Cibula D / 2018 / Surgical treatment of"intermediate risk"lymph node negative cervical cancer patients without adjuvant radiotherapy-A retrospective cohort study and review of the literature / Gynecol Oncol 151:438~443
Nakamura K / 2016 / Analysis of the effect of adjuvant radiotherapy on outcomes and complications after radical hysterectomy in FIGO stage IB1 cervical cancer patients with intermediate risk factors(GOTIC study) / World J Surg Oncol 14:173
National Comprehensive Cancer Network (NCCN) / NCCN Clinical Practice Guidelines in Oncology. Cervical cancer version 2.2020
Rotman M / 2006 / A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features : follow-up of a gynecologic oncology group study / Int J Radiat Oncol Biol Phys 65:169~176
Cibula D / 2018 / Surgical treatment of"intermediate risk"lymph node negative cervical cancer patients without adjuvant radiotherapy-A retrospective cohort study and review of the literature / Gynecol Oncol 151:438~443
Nakamura K / 2016 / Analysis of the effect of adjuvant radiotherapy on outcomes and complications after radical hysterectomy in FIGO stage IB1 cervical cancer patients with intermediate risk factors(GOTIC study) / World J Surg Oncol 14:173
National Comprehensive Cancer Network (NCCN) / NCCN Clinical Practice Guidelines in Oncology. Cervical cancer version 2.2020
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