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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 108 - 113 (6page)
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초록· 키워드
오류제보하기
Melatonin and cortisol are clinically important for diagnosing sleep and mood disorders. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary melatonin and cortisol concentrations according to the Clinical and Laboratory Standards Institute guidelines. Additionally, we compared the LC-MS/MS assay with immunoassays, ELISA (Direct Salivary Melatonin Elisa EK-DSM, Buhlmann Laboratories AG, Schonenbuch, Switzerland) and electrochemiluminescence immunoassay (Cortisol II, Roche, Mannheim, Germany), using 121 saliva samples. The LC-MS/MS assay exhibited good performance in terms of linearity, precision, accuracy, limit of detection, lower limit of quantification, extraction recovery, carry-over, and matrix effect. The LC-MS/MS assay and immunoassays showed strong correlation (Pearson’s r=0.910 for melatonin, r=0.955 for cortisol), but demonstrated a significant mean bias of 23.2% (range 54.0?143.7%) for melatonin and 48.9% (range 59.7?184.7%) for cortisol. Our LC-MS/MS assay provided more sensitive and reliable salivary melatonin and cortisol quantification results compared with immunoassays.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Claustrat B / 2015 / Melatonin: physiological effects in humans / Neurochirurgie 61:77~84
Debono M / 2009 / Modified-release hydrocortisone to provide circadian cortisol profiles / J Clin Endocrinol Metab 94:1548~1554
Blair J / 2017 / Salivary cortisol and cortisone in the clinical setting / Curr Opin Endocrinol Diabetes Obes 24:161~168
Voultsios A / 1997 / Salivary melatonin as a circadian phase marker: validation and comparison to plasma melatonin / J Biol Rhythms 12:457~466
Jung C / 2014 / Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers / BMC Endocr Disord 14:91
Debono M / 2009 / Modified-release hydrocortisone to provide circadian cortisol profiles / J Clin Endocrinol Metab 94:1548~1554
Blair J / 2017 / Salivary cortisol and cortisone in the clinical setting / Curr Opin Endocrinol Diabetes Obes 24:161~168
Voultsios A / 1997 / Salivary melatonin as a circadian phase marker: validation and comparison to plasma melatonin / J Biol Rhythms 12:457~466
Jung C / 2014 / Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers / BMC Endocr Disord 14:91
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