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논문 기본 정보

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학술저널
저자정보
Lee Min Young (Department of Laboratory Medicine Kyung Hee University School of Medicine and Kyung Hee University) Park Chan-Jeoung (Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul) Cho Young-Uk (Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul) You Eunkyoung (Department of Laboratory Medicine Inje University College of Medicine Busan Baik Hospital Busan Kor) Jang Seongsoo (Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul) Seo Eul Ju (Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul) Lee Jung-Hee (Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Yoon Dok Hyun (Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Suh Cheolwon (Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제3호
발행연도
2021.1
수록면
259 - 267 (9page)

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Background: Plasma cell myeloma (PCM) is caused by immune dysregulation. We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according to disease course and cytogenetic abnormalities. This study aimed to find a target group suitable for therapeutic use of PD-1 blockade in PCM. Methods: A total of 188 bone marrow (BM) samples from 166 PCM patients and 32 controls were prospectively collected between May 2016 and May 2017. PD-1 expression on BM T cell subsets was measured using flow cytometry. Results: At diagnosis, the median PD-1 expression on CD4+ T cells was 24.6%, which did not significantly differ from that in controls. After stem cell transplantation, PD-1 expression on CD4+ T cells was higher than that at diagnosis (P<0.001), regardless of residual disease. PD-1 expression on CD4+ T cells in patients with residual disease after chemotherapy was significantly higher than that at diagnosis (P=0.001) and after complete remission following chemotherapy (P=0.044). PD-1 expression on CD8+ T cells was higher in PCM patients with cytogenetic abnormalities, including monosomy 13, 1q gain, complex karyotype, and hypodiploidy. Conclusions: PD-1 blockade might have therapeutic potential in refractory PCM patients after chemotherapy, especially in those with high- or intermediate-risk cytogenetic abnormalities.
#Plasma cell myeloma #Immune checkpoint programmed cell death protein-1 (PD-1) #Flow cytometry #T cell subset

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참고문헌 (24)

참고문헌 신청
Patel SP / 2015 / PD-L1 expression as a predictive biomarker in cancer immunotherapy / Mol Cancer Ther 14:847~856 google schola Lesokhin AM / 2016 / Nivolumab in patients with relapsed or refractory hematologic malignancy: preliminary results of a phase Ib study / J Clin Oncol 34:2698~2704 google schola Usmani SZ / 2018 / A phase 3 randomized study of pembrolizumab (pembro) plus lenalidomide (len) and low-dose dexamethasone (Rd) versus Rd for newly diagnosed and treatment-naive multiple myeloma (MM): Keynote-185 / J Clin Oncol 36:8010 google schola Mateos MV / 2018 / A phase 3 randomized study of pembrolizumab (Pembro) plus pomalidomide (Pom) and dexamethasone (Dex) for relapsed/refractory multiple myeloma (RRMM): Keynote-183 / J Clin Oncol 36:8021 google schola Palumbo A / 2015 / Revised international staging system for multiple myeloma: a report from International Myeloma Working Group / J Clin Oncol 33:2863~2869 google schola

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