Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases

Domenico De Berardis; Gabriella Rapini; Luigi Olivieri; Agostina Giardini; Ida De Lauretis; Nicola Serroni; Laura Orsolini; Michele Fornaro; Felice Iasevoli; Sabatino Trotta; Paolo Cottura; Federica Vellante; Marco Alessandrini; Massimo Di Giannantonio

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저자정보: Domenico De Berardis (Hospital “G. Mazzini”) Gabriella Rapini (Hospital “G. Mazzini”) Luigi Olivieri (Hospital “G. Mazzini”) Agostina Giardini (Hospital “G. Mazzini”) Ida De Lauretis (Hospital “G. Mazzini”) Nicola Serroni (Hospital “G. Mazzini”) Laura Orsolini (University of Hertfordshire) Michele Fornaro (Federico II University) Felice Iasevoli (University School of Medicine “Federico II”) Sabatino Trotta (Department of Mental Health National Health Service Azienda Sanitaria Locale) Paolo Cottura (National Health Service) Federica Vellante (Department of Neuroscience Imaging and Clinical Science Chair of Psychiatry University of “G. D’Ann) Marco Alessandrini (Department of Neuroscience Imaging and Clinical Science Chair of Psychiatry University of “G. D’Ann) Massimo Di Giannantonio (University “G. D’Annunzio”)

저널정보: 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제1호

발행연도: 2021.1

수록면: 174 - 178 (5page)

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Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2/D3 receptors with preferential binding to the D3 receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A. Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.

#Cariprazine #Clozapine #Effectiveness #Efficacy #Schizophrenia #Tolerability.

참고문헌 (35)

참고문헌 신청

Galderisi S / 2018 / Interplay among psychopathologic variables, personal resources, context-related factors, and real-life functioning in individuals with schizophrenia : a network analysis / JAMA Psychiatry 75:396~404

Iasevoli F / 2016 / Treatment resistant schizophrenia is associated with the worst community functioning among severely-ill highly-disabling psychiatric conditions and is the most relevant predictor of poorer achievements in functional milestones / Prog Neuropsychopharmacol Biol Psychiatry 65:34~48

De Berardis D / 2013 / Safety and efficacy of combined clozapine-azathioprine treatment in a case of resistant schizophrenia associated with Behçet's disease : a 2-year follow-up / Gen Hosp Psychiatry 35:213

De Berardis D / 2019 / Treatment resistance in psychiatry: risk factors, biology, and management / Springer :349~367

De Berardis D / 2018 / Safety of antipsychotics for the treatment of schizophrenia : a focus on the adverse effects of clozapine / Ther Adv Drug Saf 9:237~256

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