지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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PURPOSE: Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopeniais related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to chronic diseases, andeven falling. Despite the many clinical studies on skeletal muscle atrophy, a little study had been about the exact mechanism of skeletalmuscle atrophy at the molecular level. In 2017, A disease code (ICD-10-CM) for skeletal muscle atrophy related to sarcopenia wasannounced to attempt a clinical approach in the United States. According to these approaches, non-invasive clinical treatment is themost effective method for treating skeletal muscle atrophy. The purpose of this study was to analyze the molecular mechanisms of muscularexercise and related skeletal muscle atrophy factors. METHODS: This systemic review focused on skeletal muscle atrophy and muscular exercise. The keywords were used on “MeSH: muscleatrophy OR skeletal muscle atrophy OR muscle OR atrophy AND physical exercise OR exercise OR exercise training” for Englishand Korean. This paper searched PubMED, OVIDMEDLINE, and EMBASE for literature consideration. RESULTS: Skeletal muscle atrophy was related to a complex molecular network, and exercise affects IGF-1/Akt/mTOR signaling. Therelated skeletal muscle atrophy factors were evaluated as MurF1, MAFbx, IGF-1, and NFkB. We proposed new related factors such asATF 4, Gadd45a, and p21; however, the results related to exercise were not shown in recent studies. CONLCUSIONS: In conclusion, we identified skeletal muscle atrophy factors at the molecular level of muscle physiology, and thesenew factors may become an interesting field of study in clinical human trial and animal studies.
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참고문헌 (51)
참고문헌 신청
김경민 / 2020 / 근감소증을 가진 고령자의 근육량, 근력 및 신체 수행력에 저항 운동의 효과: 체계적 고찰과 메타분석 / 운동과학 29(2):109~120
Walston JD / 2012 / Sarcopenia in older adults / Curr Opin Rheumatol 24(6):623~627
Brown JC / 2016 / Sarcopenia and mortality among a population-based sample of community-dwelling older adults / J Cachexia Sarcopenia Muscle 7(3):290~298
Sobestiansky S / 2019 / Sarcopenia prevalence and associations with mortality and hospitalisation by various sarcopenia definitions in 85–89year old community-dwelling men : a report from the ULSAM study / BMC Geriatrics 19(1):318
Zhang X / 2018 / Sarcopenia as a predictor of all-cause mortality among older nursing home residents: a systematic review and meta-analysis / BMJ Open 8(11):e021252
Walston JD / 2012 / Sarcopenia in older adults / Curr Opin Rheumatol 24(6):623~627
Brown JC / 2016 / Sarcopenia and mortality among a population-based sample of community-dwelling older adults / J Cachexia Sarcopenia Muscle 7(3):290~298
Sobestiansky S / 2019 / Sarcopenia prevalence and associations with mortality and hospitalisation by various sarcopenia definitions in 85–89year old community-dwelling men : a report from the ULSAM study / BMC Geriatrics 19(1):318
Zhang X / 2018 / Sarcopenia as a predictor of all-cause mortality among older nursing home residents: a systematic review and meta-analysis / BMJ Open 8(11):e021252
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