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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 227 - 236 (10page)
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In this study, we have developed 3D8 scFv transgenic pig (TG) by microinjection of fertilized one-cell pig zygotes (2.17%). The effect of 3D8 scFv TG on porcine reproductive and respiratory syndrome virus (PRRSV) resistance were evaluated through PRRSV VR2332 (1×10 3 TCID50/mL) challenge and transmission experiments. As a result, the average daily weight gain (ADWG) of TG increased compared to the wild type pigs (WT) in PRRSV challenge groups and the serum viremia levels of the TG was significantly lower than of WT on the 7 day and 21 day after infection, meaning that the viral shedding was suppressed by 3D8 scFv expression. These results suggest that the expression of 3D8 scFv in pig could suppress spreading of infected virus to pigs sharing a room.
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참고문헌 (35)
참고문헌 신청
양승혁 / 2019 / PRRS가 한국 양돈산업에 미치는 경제적 손실 / 한돈 11:310~315
Benfield DA / 1992 / Characterization of swine infertility and respiratory syndrome(SIRS)virus(isolate ATCC VR-2332) / J Vet Diagn Investig 4:127~133
Byun SJ / 2020 / The 3D8 single chain variable fragment protein suppresses Newcastle disease virus transmission in transgenic chickens / BMC Vet Res 6:273
Byun SJ / 2017 / Transgenic Chickens Expressing the 3D8 Single Chain Variable Fragment Protein Suppress Avian Influenza Transmission / Sci Rep 7:5938
Collins JE / 1992 / Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gnotobiotic pigs / J Vet Diagn Investig 4:117~126
Benfield DA / 1992 / Characterization of swine infertility and respiratory syndrome(SIRS)virus(isolate ATCC VR-2332) / J Vet Diagn Investig 4:127~133
Byun SJ / 2020 / The 3D8 single chain variable fragment protein suppresses Newcastle disease virus transmission in transgenic chickens / BMC Vet Res 6:273
Byun SJ / 2017 / Transgenic Chickens Expressing the 3D8 Single Chain Variable Fragment Protein Suppress Avian Influenza Transmission / Sci Rep 7:5938
Collins JE / 1992 / Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gnotobiotic pigs / J Vet Diagn Investig 4:117~126
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