지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.9
- 수록면
- 16 - 28 (13page)
이용수
초록· 키워드
오류제보하기
Background: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccines do not provide full cross-protection, mainly due to the virus genetic variability. Despite this, vaccines based on modified-live PRRSV (PRRSV-MLV) reduce the disease impact.
Objectives: To assess the efficacy of two commercial vaccines—one based on PRRSV1 (PRRSV1-MLV) and another on PRRSV2 (PRRSV2-MLV)—against a Japanese PRRSV2 field strain.
Methods: Two groups of three-week-old piglets were vaccinated (G1: PRRSV1-MLV; G2: PRRSV2-MLV) and two were kept as non-vaccinated (INF and CTRL). One month later, G1, G2, and INF were challenged with a PRRSV2 field strain.
Results: After the challenge, clinical signs were only observed in INF. Moreover, the highest rectal temperatures and values for the area under the curve (AUC) were observed in INF. Regarding viral detection, both AUC and the proportion of positive samples in blood were higher in INF. In G1, viremic animals never reached 100%. At necropsy (21 d after the challenge), differences for titers among groups were only found in tonsils (G1 < G2 and INF). One animal (belonging to G1) was negative in all tissues. Regarding humoral responses, G1 and G2 seroconverted after vaccination, as detected in the corresponding enzyme-linked immunosorbent assay. Specific neutralizing antibodies (NA) against PRRSV1-MLV were already detected at 14 d after vaccination in G1, showing a significant booster after the challenge, while PRRSV2-MLV NA were detected in G2 at the end of the experiment.
Conclusions: Despite genetic differences, PRRSV1-MLV has been demonstrated to confer partial protection against a Japanese PRRSV2 strain, at least as good as PRRSV2-MLV.
Objectives: To assess the efficacy of two commercial vaccines—one based on PRRSV1 (PRRSV1-MLV) and another on PRRSV2 (PRRSV2-MLV)—against a Japanese PRRSV2 field strain.
Methods: Two groups of three-week-old piglets were vaccinated (G1: PRRSV1-MLV; G2: PRRSV2-MLV) and two were kept as non-vaccinated (INF and CTRL). One month later, G1, G2, and INF were challenged with a PRRSV2 field strain.
Results: After the challenge, clinical signs were only observed in INF. Moreover, the highest rectal temperatures and values for the area under the curve (AUC) were observed in INF. Regarding viral detection, both AUC and the proportion of positive samples in blood were higher in INF. In G1, viremic animals never reached 100%. At necropsy (21 d after the challenge), differences for titers among groups were only found in tonsils (G1 < G2 and INF). One animal (belonging to G1) was negative in all tissues. Regarding humoral responses, G1 and G2 seroconverted after vaccination, as detected in the corresponding enzyme-linked immunosorbent assay. Specific neutralizing antibodies (NA) against PRRSV1-MLV were already detected at 14 d after vaccination in G1, showing a significant booster after the challenge, while PRRSV2-MLV NA were detected in G2 at the end of the experiment.
Conclusions: Despite genetic differences, PRRSV1-MLV has been demonstrated to confer partial protection against a Japanese PRRSV2 strain, at least as good as PRRSV2-MLV.
목차
ABSTRACT
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Evaluation of virus suppression induced by PRRSV-specific T cells in type 1 PRRSV-infected pigs
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Acute porcine reproductive and respiratory syndrome outbreaks in immunized sow herds: from occurrence to stabilization under whole herd vaccination strategy
Korean Journal of Veterinary Research(대한수의학회지)
2018 .07
-
돼지생식기호흡기증후군바이러스(PRRSV)의 전장 유전체 염기서열(whole-genome sequencing) 분석을 위한 차세대 염기서열 분석법의 활용
한국가축위생학회지
2016 .01
-
Genetic diversity and phylogenetic analysis of porcine reproductive and respiratory syndrome virus in southern China from 2007 to 2014
Journal of Veterinary Science
2017 .09
-
Age-specific Prevalence of Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus Type 2, and Mycoplasma hyopneumoniae in Korea Pig Farms
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .03
-
PRRS 양성농장의 사육단계별 구강액과 혈액을 이용한 PRRSV와 항체 검출 비교
한국가축위생학회지
2020 .01
-
A new recombined porcine reproductive and respiratory syndrome virus virulent strain in China
Journal of Veterinary Science
2018 .01
-
Effects of herd closure and medication programs on the infection of NADC30-like PRRSV in pig farms
Journal of Veterinary Science
2024 .11
-
Preliminary assessment of correlation between T-lymphocyte responses and control of porcine reproductive and respiratory syndrome virus (PRRSV) in piglets born after in-utero infection of a type 2 PRRSV
Korean Journal of Veterinary Research(대한수의학회지)
2018 .05
-
A rapid and quantitative fluorescent microsphere immunochromatographic strip test for detection of antibodies to porcine reproductive and respiratory syndrome virus
Journal of Veterinary Science
2020 .07
-
T cells-mediated immune response induced by chimeric virus expressing porcine reproductive and respiratory syndrome virus(PRRSV)-derived peptides
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Phenotypic and genotypic analyses of an attenuated porcine reproductive and respiratory syndrome virus strain after serial passages in cultured porcine alveolar macrophages
Journal of Veterinary Science
2018 .05
-
Development of a multiplex qRT-PCR assay for detection of African swine fever virus, classical swine fever virus and porcine reproductive and respiratory syndrome virus
Journal of Veterinary Science
2021 .11
-
Transcriptome profiling identifies immune response genes against porcine reproductive and respiratory syndrome virus and Haemophilus parasuis co-infection in the lungs of piglets
Journal of Veterinary Science
2022 .01
-
Development of a biosensor from aptamers for detection of the porcine reproductive and respiratory syndrome virus
Journal of Veterinary Science
2020 .09
-
Ortho-phenylphenol을 주성분으로 하는 훈증소독제의 돼지열병바이러스와 돼지생식기호흡기증후군바이러스에 대한 살바이러스 효과
한국가축위생학회지
2016 .01
-
Genomic characterization and pathogenic study of two porcine reproductive and respiratory syndrome viruses with different virulence in Fujian, China
Journal of Veterinary Science
2018 .05
-
An enhanced immunochromatographic strip test using colloidal gold nanoparticle-labeled dual-type N proteins for detection of antibodies to PRRS virus
Journal of Veterinary Science
2018 .07
-
Generation of a cold-adapted PRRSV with a nucleotide substitution in the ORF5 and numerous mutations in the hypervariable region of NSP2
Journal of Veterinary Science
2020 .11
-
Development of an immunochromatographic strip for detection of antibodies against porcine reproductive and respiratory syndrome virus
Journal of Veterinary Science
2017 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
태권도 교육프로그램이 유아의 정서발달에 미치는 영향
이필영
,
윤지희
무도연구소지
2000
.12
Evaluation of the Stability of the Foot-and-mouth Disease (FMD) Virus Particle, which is a Critical Factor in the Efficacy of the FMD Vaccine
Young Joon KO
,
Jong Hyeon PARK
,
Sun Young PARK
외 1명
한국생물공학회 학술대회
2023
.10
Efficacy of Binary Ethylenimine for Foot-and-mouth Disease Virus Inactivation for Vaccine Production
Jae Young KIM
,
Sang Hyun PARK
,
Sun Young PARK
외 3명
한국생물공학회 학술대회
2023
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-24-02-088230740