지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 22 - 28 (7page)
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초록· 키워드
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Purpose: The purpose of this study was to investigate the clinical outcomes of non-carbapenem treatment for urinary tract infections (UTIs) caused by extendedspectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli ) in young children. Methods: We retrospectively reviewed the medical records of children under 2 years of age who were diagnosed and treated for UTIs caused by ESBL-producing E. coli from September 2014 to March 2020. Results: Forty-three children under 2 years of age were treated with non-carbapenem antimicrobials for UTIs caused by ESBL-producing E. coli without bloodstream infections. The overall clinical and microbiological success rates for empirical antimicrobial treatment were 90.7% and 97.7%. Three of the patients (7.0%) experienced a relapse of UTI within a month. An in vitro susceptibility test showed that two patients were sensitive and one was resistant to the antimicrobial treatments. Furthermore, there were no significant differences in the time to defervescence, clinical success, microbiological success, and relapse rate between the susceptible (n=13) and non-susceptible groups (n=30). Conclusion: In this study, the overall relapse rate of patients treated with noncarbapenem antimicrobials was 7.0%. The patients showed high success rates in the clinical and microbiological responses to the non-carbapenems regardless of the results of the in vitro antimicrobial susceptibility test. These results provide evidence that non-carbapenems may be viable alternative treatments for UTIs caused by ESBL-producing E. coli .
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참고문헌 (35)
참고문헌 신청
Zorc JJ / 2005 / Diagnosis and management of pediatric urinary tract infections / Clin Microbiol Rev 18:417~422
Briongos-Figuero LS / 2012 / Epidemiology, risk factors and comorbidity for urinary tract infections caused by extended-spectrum beta-lactamase (ESBL)-producing enterobacteria / Int J Clin Pract 66:891~896
Jean SS / 2016 / Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region:Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013 / Int J Antimicrob Agents 47:328~334
Megged O / 2014 / Extended-spectrum β-lactamase-producing bacteria causing community-acquired urinary tract infections in children / Pediatr Nephrol 29:1583~1587
Fan NC / 2014 / Rise of community-onset urinary tract infection caused by extendedspectrum β-lactamase-producing Escherichia coli in children / J Microbiol Immunol Infect 47:399~405
Briongos-Figuero LS / 2012 / Epidemiology, risk factors and comorbidity for urinary tract infections caused by extended-spectrum beta-lactamase (ESBL)-producing enterobacteria / Int J Clin Pract 66:891~896
Jean SS / 2016 / Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region:Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013 / Int J Antimicrob Agents 47:328~334
Megged O / 2014 / Extended-spectrum β-lactamase-producing bacteria causing community-acquired urinary tract infections in children / Pediatr Nephrol 29:1583~1587
Fan NC / 2014 / Rise of community-onset urinary tract infection caused by extendedspectrum β-lactamase-producing Escherichia coli in children / J Microbiol Immunol Infect 47:399~405
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