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논문 기본 정보

자료유형
학술저널
저자정보
Jihye Kim (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Wonseok Kang (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Dong Hyun Sinn (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Geum-Youn Gwak (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Yong-Han Paik (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Moon Seok Choi (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Joon Hyeok Lee (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Kwang Cheol Koh (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Seung Woon Paik (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제26권 제4호
발행연도
2020.1
수록면
516 - 528 (13page)

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Background/Aims: Although hepatocellular carcinoma (HCC) is notorious for its high recurrence rate, some patients do not experience recurrence for more than 5 years after resection or radiofrequency ablation for early-stage HCC. For those with five recurrence-free period, the risk of HCC recurrence within the next 5 years remains unknown. Methods: A total of 1,451 consecutive patients (median, 55 years old; males, 79.0%; hepatitis B virus-related, 79.3%) with good liver function (Child-Pugh class A) diagnosed with early-stage HCC by Barcelona Clinic Liver Cancer Staging and received radiofrequency ablation or resection as an initial treatment between 2005 and 2010 were analyzed. Results: During a median follow-up period of 8.1 years, 961 patients (66.2%) experienced HCC recurrence. The cumulative recurrence rates increased to 39.7%, 60.3%, and 71.0% at 2, 5, and 10 years, respectively, and did not reach a plateau. Five years after HCC diagnosis, 487 patients were alive without experiencing a recurrence. Among them, during a median of 3.9 additional years of follow-up (range, 0.1?9.0 years), 127 patients (26.1%) experienced recurrence. The next 5-year cumulative recurrence rate (5?10 years from initial diagnosis) was 27.0%. Male sex, higher fibrosis-4 scores, and alpha-fetoprotein levels at 5 years were associated with later HCC recurrence among patients who did not experience recurrence for more than 5 years. Conclusions: The HCC recurrence rate following 5 recurrence-free years after HCC treatment was high, indicating that HCC patients warrant continued HCC surveillance, even after 5 recurrence-free years.
#Carcinoma #Hepatocellular #Treatment #Long-term #Recurrence

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참고문헌 (49)

참고문헌 신청
Forner A / 2012 / Hepatocellular carcinoma / Lancet 379:1245~1255 google schola Sayiner M / 2019 / Disease burden of hepatocellular carcinoma : a global perspective / Dig Dis Sci 64:910~917 google schola Roayaie S / 2009 / A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma / Gastroenterology 137:850~855 google schola Shen YC / 2010 / Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma(HCC) : a meta-regression approach / J Hepatol 52:889~894 google schola Belghiti J / 1991 / Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis / Ann Surg 214:114~117 google schola

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