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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 686 - 696 (11page)
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초록· 키워드
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Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver disease scores >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, however it does not provide survival benefits beyond 1 month. Recent preclinical and early clinical studies in AH aided understanding of the disease and presented opportunities for new therapeutic options targeting inflammation, oxidative stress, liver regeneration and modification of intestinal microbiota. In this comprehensive review, we discuss promising preclinical results and ongoing clinical trials evaluating novel therapeutic agents for the treatment of severe AH.
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등록된 정보가 없습니다.
참고문헌 (84)
참고문헌 신청
Szabo G / 2019 / Alcohol-related liver disease: areas of consensus, unmet needs and opportunities for further study / Hepatology 69:2271~2283
Mathurin P / 2012 / Management of alcoholic hepatitis / J Hepatol 2012;56 Suppl 56(Suppl 1):S39~S45
Lucey MR / 2009 / Alcoholic hepatitis / N Engl J Med 360:2758~2769
Szabo G / 2017 / Gut-liver axis and sterile signals in the development of alcoholic liver disease / Alcohol Alcohol 52:414~424
Saha B / 2019 / Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis / Hepatology 70:1134~1149
Mathurin P / 2012 / Management of alcoholic hepatitis / J Hepatol 2012;56 Suppl 56(Suppl 1):S39~S45
Lucey MR / 2009 / Alcoholic hepatitis / N Engl J Med 360:2758~2769
Szabo G / 2017 / Gut-liver axis and sterile signals in the development of alcoholic liver disease / Alcohol Alcohol 52:414~424
Saha B / 2019 / Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis / Hepatology 70:1134~1149
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