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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 275 - 286 (12page)
이용수
초록· 키워드
오류제보하기
Purpose: OnabotulinumtoxinA (BoNT-A) is a promising therapy for treating neurogenic detrusor overactivity (NDO) in individuals with spinal cord injury (SCI). This systematic review and meta-analysis aimed to carry out an in-depth review and to make an objective estimation of the efficacy and safety of BoNT-A on NDO after SCI. Methods: The PubMed, Embase, and Cochrane databases were searched for all relevant articles published from 2001 to 2016 that referred to NDO, SCI, and BoNT-A or botulinum toxin A. All data were recorded in an Excel spreadsheet by 2 individual reviewers. Review Manager version 5.3 was used to carry out the meta-analysis. Results: This analysis included 17 studies involving 1,455 patients. Compared with placebo and baseline, BoNT-A was effective in increasing maximum cystometric capacity, volume at first involuntary detrusor contraction, cystometric bladder capacity (all P<0.00001), compliance (P=0.001), and the number of patients with complete dryness (P=0.0003), and decreasing detrusor pressure, the number of patients with no involuntary detrusor contractions, the maximum flow rate, the incidence of detrusor overactivity (all P<0.00001), and the number of urinary incontinence episodes (P=0.001). There were no statistically significant differences between doses of 200 U and 300 U or between injections into the detrusor and submucosa. There were no life-threatening adverse events. Conclusions: BoNT-A is effective and safe in treating NDO after SCI. There were no statistically significant differences between doses of 200 U and 300 U or between injecting into the detrusor and submucosa. However, more high-quality randomized controlled trials are still needed.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Leitner L / 2014 / Protocol for a prospective magnetic resonance imaging study on supraspinal lower urinary tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity / BMC Urol 14:68
Tetreault LA / 2017 / The natural history of degenerative cervical myelopathy and the rate of hospitalization following spinal cord injury: an updated systematic review / Global Spine J 7(3 Suppl):28S~34S
Hu HZ / 2016 / Pathophysiology, clinical importance, and management of neurogenic lower urinary tract dysfunction caused by suprasacral spinal cord injury / J Vet Intern Med 30:1575~1588
Schöps TF / 2015 / Neurogenic lower urinary tract dysfunction (NLUTD) in patients with spinal cord injury: long-term urodynamic findings / BJU Int 115(Suppl 6):33~38
Andy UU / 2015 / Validation of a self-administered instrument to measure adherence to anticholinergic drugs in women with overactive bladder / Neurourol Urodyn 34:424~428
Tetreault LA / 2017 / The natural history of degenerative cervical myelopathy and the rate of hospitalization following spinal cord injury: an updated systematic review / Global Spine J 7(3 Suppl):28S~34S
Hu HZ / 2016 / Pathophysiology, clinical importance, and management of neurogenic lower urinary tract dysfunction caused by suprasacral spinal cord injury / J Vet Intern Med 30:1575~1588
Schöps TF / 2015 / Neurogenic lower urinary tract dysfunction (NLUTD) in patients with spinal cord injury: long-term urodynamic findings / BJU Int 115(Suppl 6):33~38
Andy UU / 2015 / Validation of a self-administered instrument to measure adherence to anticholinergic drugs in women with overactive bladder / Neurourol Urodyn 34:424~428
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Anorectal Manometric and Urodynamic Parameters According to the Spinal Cord Injury Lesion
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Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation
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