지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 53 - 61 (9page)
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초록· 키워드
오류제보하기
Purpose: OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment.
Methods: A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogenic detrusor overactivity treatment. MEDLINE, Embase, and the CENTRAL were employed. Reference lists of retrieved studies were reviewed carefully.
Results: Six publications involving 871 patients, which compared onabotulinumtoxinA with a placebo were analyzed. Efficacy of onabotulinumtoxinA treatment was shown as a reduction of the mean number of urinary incontinence episodes per day (mean difference, -1.41; 95% confidence interval [CI], -1.70 to -1.12; P<0.00001), maximum cystometric capacity (135.48; 95% CI, 118.22–152.75; P<0.00001), and maximum detrusor pressure (-32.98; 95% CI, -37.33 to -28.62; P<0.00001). Assessment of adverse events revealed that complications due to onabotulinumtoxinA injection were localized primarily to the urinary tract.
Conclusions: This meta-analysis suggests that onabotulinumtoxinA is an effective treatment for neurogenic detrusor overactivity with localized advent events
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function : report from the Standardisation Sub-committee of the International Continence Society /
Abrams P / 2003 / The standardisation of terminology in lower urinary tract function : report from the standardisation sub-committee of the International Continence Society /
Apostolidis A / 2013 / An exploratory, placebo-controlled, dose-response study of the efficacy and safety of onabotulinumtoxinA in spinal cord injury patients with urinary i
Chancellor MB / 2013 / OnabotulinumtoxinA improves quality of life in patients with neurogenic detrusor overactivity / Neurology 81 : 841 ~ 848
Cruz F / 2011 / Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-c
Abrams P / 2003 / The standardisation of terminology in lower urinary tract function : report from the standardisation sub-committee of the International Continence Society /
Apostolidis A / 2013 / An exploratory, placebo-controlled, dose-response study of the efficacy and safety of onabotulinumtoxinA in spinal cord injury patients with urinary i
Chancellor MB / 2013 / OnabotulinumtoxinA improves quality of life in patients with neurogenic detrusor overactivity / Neurology 81 : 841 ~ 848
Cruz F / 2011 / Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-c
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