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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 826 - 830 (5page)
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We retrospectively reviewed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who wereadmitted to an intensive care unit in Daegu, South Korea. The outcomes of patients who did (cases) or did not (controls) receivedarunavir-cobicistat (800?150 mg) therapy were compared. Fourteen patients received darunavir-cobicistat treatment, and 96 receivedother antiviral therapy (controls). Overall, the darunavir-cobicistat group comprised patients with milder illness, and thecrude mortality rate of all patients in the darunavir-cobicistat group was lower than that in the controls [odds ratio (OR) 0.20, 95%confidence interval (CI) 0.04?0.89, p=0.035]. After 1:2 propensity-score matching, there were 14 patients in the darunavir-cobicistatgroup, and 28 patients in the controls. In propensity score-matched analysis, the darunavir-cobicistat group had lower mortalitythan the controls (OR 0.07, 95% CI 0.01?0.52, p=0.009). In conclusion, darunavir-cobicistat therapy was found to be associatedwith a significant survival benefit in critically ill patients with SARS-CoV-2 infection.
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참고문헌 (8)
참고문헌 신청
Chu CM / 2004 / Role of lopinavir/ritonavir in the treatment of SARS : initial virological and clinical findings / Thorax 59:252~256
China News Network / Abidol and darunavir can effectively inhibit coronavirus
Dong L / 2020 / Discovering drugs to treat coronavirus disease 2019(COVID-19) / Drug Discov Ther 14:58~60
James M. Sanders / 2020 / Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) / JAMA
Curran A / 2015 / Rezolsta®(darunavir/cobicistat) : first boosted protease inhibitor co-formulated with cobicistat / AIDS Rev 17:114~120
China News Network / Abidol and darunavir can effectively inhibit coronavirus
Dong L / 2020 / Discovering drugs to treat coronavirus disease 2019(COVID-19) / Drug Discov Ther 14:58~60
James M. Sanders / 2020 / Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) / JAMA
Curran A / 2015 / Rezolsta®(darunavir/cobicistat) : first boosted protease inhibitor co-formulated with cobicistat / AIDS Rev 17:114~120
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