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학술저널
저자정보
Baldelli Luke (Division of Gastroenterology and Hepatology University of North Carolina Chapel Hill NC USA) Marjot Thomas (Oxford Liver Unit Translational Gastroenterology Unit Oxford University Hospitals NHS Foundation Trust University of Oxford Oxford UK) Barnes Eleanor (Oxford Liver Unit Translational Gastroenterology Unit Oxford University Hospitals NHS Foundation Trust University of Oxford Oxford UK) Barritt A. Sidney (Division of Gastroenterology and Hepatology University of North Carolina Chapel Hill NC USA) Webb Gwilym J. (Cambridge Liver Unit Addenbrooke's Hospital Cambridge UK) Moon Andrew M. (Division of Gastroenterology and Hepatology University of North Carolina Chapel Hill NC USA)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제17권 제1호
발행연도
2023.1
수록면
12 - 23 (12page)
DOI
10.5009/gnl220327

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The impact of the coronavirus disease 2019 (COVID-19) pandemic has been immense, and it continues to have lasting repercussions. While the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus primarily infects the respiratory system, other organ systems are affected, including the liver. Scientific knowledge on the role of SARS-CoV-2 infection and liver injury has evolved rapidly, with recent data suggesting specific hepatotropism of SARS-CoV-2. Moreover, additional concerns have been raised in regard to long-term liver damage, related to emerging cases of post-COVID-19 cholangiopathy and chronic cholestasis. Great effort has also been focused on studying how specific subpopulations with chronic medical conditions might be disproportionately impacted by COVID-19. One such population includes individuals with chronic liver disease (CLD) and cirrhosis, with an expanding body of research indicating these patients being particularly susceptible to adverse outcomes. In this review, we provide an updated summary on the current pathogenesis and mechanism of liver injury in the setting of SARS-CoV-2 infection, the association between health outcomes and SARS-CoV-2 infection in patients with CLD, and the unique consequences of the COVID-19 pandemic on the routine care of patients with CLD.

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