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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제3호
- 발행연도
- 2020.1
- 수록면
- 109 - 118 (10page)
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Runt related transcription factors (RUNX), a family of well-known transcription factors, play key regulatory roles in diverse biological processes, such as proliferation, differentiation, and DNA repair. Of RUNX family, RUNX3 is the least well characterized of the three family members. Nevertheless, the role of RUNX3 as a key regulator in essential biological pathways has been reported and inactivation of RUNX3 leads to a variety of disease, such as cancer, via regulation of Wnt signaling and K-ras mutations in many mammalian tissues. Recent studies using RUNX3-deficient cells and mice revealed an association with hematopoiesis and hypersensitivity to granulocyte- colony stimulating factor. Nevertheless, protein dynamics associated with RUNX3 remain poorly understood. In the present study, we performed a large-scale protein study from Runx3 knockout (KO) mouse embryonic stem cells (mESC) using a stable isotope labeling by amino acids (SILAC)-based quantitative proteomics approach. The results showed that 67 proteins were significantly up and downregulated after Runx3 KO. Bioinformatic analyses that revealed that these proteins have diverse biological functions, such as substances transport and cellular structure. Thus, our results enhance our current understanding of the function of RUNX3 in mESCs and suggest potential roles for RUNX proteins in diverse diseases. Additionally, our results can be used as a database to help us understand the mechanism of action of RUNX3.
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참고문헌 (23)
참고문헌 신청
Miyoshi H / 1991 / t(8;21)breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1 / Proc Natl Acad Sci USA 88:10431~10434
Lee SH / 2017 / Roles of RUNX in hypoxia-induced responses and angiogenesis / Adv Exp Med Biol 962:449~469
Li QL / 2002 / Causal relationship between the loss of RUNX3 expression and gastric cancer / Cell 109:113~124
Ito K / 2008 / RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis / Cancer Cell 14:226~237
Lee YS / 2013 / Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma / Cancer Cell 24:603~616
Lee SH / 2017 / Roles of RUNX in hypoxia-induced responses and angiogenesis / Adv Exp Med Biol 962:449~469
Li QL / 2002 / Causal relationship between the loss of RUNX3 expression and gastric cancer / Cell 109:113~124
Ito K / 2008 / RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis / Cancer Cell 14:226~237
Lee YS / 2013 / Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma / Cancer Cell 24:603~616
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