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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제4호
- 발행연도
- 2020.1
- 수록면
- 171 - 176 (6page)
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초록· 키워드
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Globally, colon cancer is increased gradually and known as one of the major causes of cancer death. Stevia, a substitute of sugar, is known to have many components including alpha-tocopherol and anthocyanin etc, as antioxidants. This study's purpose is to investigate whether stevia plant extract can have a protective effect against colon carcinogenesis induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) in mice. Total 30 male ICR mice were divided into 2 groups; AOM/DSS treatment (control group), AOM/DSS + stevia extract (0.5%, in drinking water). After acclimation for 1 week, five weeks old mice received three intraperitoneal AOM (10 mg/kg b.w.) injections weekly for 3 weeks (0?2nd weeks of the experiment) and 2% DSS as drinking water for the next one week. AIN-76A purified rodent diet and 0.5% stevia extract water were supplied to the animals for 6 weeks. The colons of mice were collected and the number of aberrant crypt foci (ACF) and aberrant crypts (ACs) in colonic mucosa were counted after staining with methylene blue. Malondialdehyde (MDA) concentration in feces were determined. The numbers of ACF and ACs were significantly (p<0.01) decreased in stevia-treated group compared with the control group. The MDA concentration in feces was also significantly (p<0.01) decreased in stevia-treated group compared with the control group. In histopathology of colonic epithelium, hyperplasia of colonic epithelium was less observed in stevia- treated group. These results indicate that stevia has a protective effect against colon carcinogenesis induced by AOM/DSS in mice and further study needs to illustrate the protective mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Haggar FA / 2009 / Colorectal cancer epidemiology : incidence, mortality, survival, and risk factors / Clin Colon Rectal Surg 22:191~197
De Robertis M / 2011 / The AOM/DSS murine model for the study of colon carcinogenesis : from pathways to diagnosis and therapy studies / J Carcinog 10:9
Chen J / 2009 / The signal pathways in azoxymethaneinduced colon cancer and preventive implications / Cancer Biol Ther 8:1313~1317
Madrigal-Bujaidar E / 2013 / Grapefruit juice su-ppresses azoxymethane-induced colon aberrant crypt formation and induces antioxidant capacity in mice / Asian Pac J Cancer Prev 14:6851~6856
Niedernhofer LJ / 2003 / Malondialdehyde, a product of lipid peroxi-dation, is mutagenic in human cells / J Biol Chem 278:31426~31433
De Robertis M / 2011 / The AOM/DSS murine model for the study of colon carcinogenesis : from pathways to diagnosis and therapy studies / J Carcinog 10:9
Chen J / 2009 / The signal pathways in azoxymethaneinduced colon cancer and preventive implications / Cancer Biol Ther 8:1313~1317
Madrigal-Bujaidar E / 2013 / Grapefruit juice su-ppresses azoxymethane-induced colon aberrant crypt formation and induces antioxidant capacity in mice / Asian Pac J Cancer Prev 14:6851~6856
Niedernhofer LJ / 2003 / Malondialdehyde, a product of lipid peroxi-dation, is mutagenic in human cells / J Biol Chem 278:31426~31433
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