American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice

Chunhao Yu; Xiao-Dong Wen; Zhiyu Zhang; Chun-Feng Zhang; Xiao-Hui Wu; Adiba Martin; Wei Du; Tong-Chuan He; Chong-Zhi Wang; Chun-Su Yuan

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자료유형: 학술저널

저자정보: Chunhao Yu (University of Chicago) Xiao-Dong Wen (University of Chicago) Zhiyu Zhang (University of Chicago) Chun-Feng Zhang (University of Chicago) Xiao-Hui Wu (University of Chicago) Adiba Martin (University of Chicago) Wei Du (University of Chicago) Tong-Chuan He (University of Chicago) Chong-Zhi Wang (University of Chicago) Chun-Su Yuan (University of Chicago)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.39 No.3

발행연도: 2015.7

수록면: 14 - 21 (8page)

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Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice model. However, the nude mouse model is not a gutspecific colon carcinogenesis animal model.
Methods: In this study, an experimental colitis and colitis-associated colorectal carcinogenesis mouse model, chemically induced by azoxymethane/dextran sodium sulfate (DSS) was established and the effects of oral AG were evaluated. The contents of representative ginseng saponins in the extract were determined.
Results: AG significantly reduced experimental colitis measured by the disease activity index scores. This suppression of the experimental colitis was not only evident during DSS treatment, but also very obvious after the cessation of DSS, suggesting that the ginseng significantly promoted recovery from the colitis. Consistent with the anti-inflammation data, we showed that ginseng very significantly attenuated azoxymethane/DSS-induced colon carcinogenesis by reducing the colon tumor number and tumor load.
The ginseng also effectively suppressed DSS-induced proinflammatory cytokines activation using an enzyme-linked immunosorbent assay array, in which 12 proinflammatory cytokine levels were assessed, and this effect was supported subsequently by real-time polymerase chain reaction data.
Conclusion: AG, as a candidate of botanical-based colon cancer chemoprevention, should be further investigated for its potential clinical utility.

#American ginseng #azoxymethane #carcinogenesis #chemoprevention #dextran sodium sulfate

참고문헌 (46)

참고문헌 신청

Qaseem A / 2012 / Clinical Guidelines Committee of the American College of Physicians. Screening for colorectal cancer: a guidance statement from the American College of Physicians / Ann Intern Med 156:378~386

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