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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Excessive intake of red meat has been associated with colon carcinogenesis. The effect of hemin and zinc on colon carcinogenesis was investigated in male ICR mice. After acclimation for 1 week, five-week-old mice received three s.c. injections (0-2nd weeks of the experiment) of azoxymethane (AOM; 10 mg/kg b.w.) weekly and were treated by 2% dextran sodium sulfate (DSS) in drinking water for the next 1 week to induce aberrant crypt foci (ACF). Mice were fed on AIN-76A purified rodent diet for 6 weeks. There were three experimental groups; control, hemin, and hemin + zinc groups. The daily oral doses of hemin and zinc were 534 mg/kg and 55 mg/kg b.w., respectively. After staining colonic mucosa with 0.2% methylene blue, the ACF, aberrant crypts (AC), and polyps were counted. Lipid peroxidation in liver was evaluated by thiobarbituric acid-reactive substances (TBARS) assay. The numbers of AC, ACF, large ACF (i.e., ≥4 AC/ACF), and polyps in the hemin group were higher than those in the control group. In hemin + zinc group, the numbers of AC, ACF, large ACF were significantly lower compared to the hemin or control groups (p < 0.05), and the number of polyps was also significantly lower compared to that in the hemin group (p < 0.05). The TBARS level in the livers of the hemin + zinc group was significantly lower than that of the hemin group (p < 0.05). These results suggest that hemin enhances colon carcinogenesis and that co-treatment with zinc can protect against the induction of colon carcinogenesis.
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참고문헌 (23)
참고문헌 신청
Awasthi YC / 2003 / Role of 4-hydroxynonenal in stress-mediated apoptosis signaling / Mol Aspects Med 24:219~230
Bastide NM / 2011 / Heme Iron from Meat and Risk of Colorectal Cancer: A Meta-analysis and a Review of the Mechanisms Involved / Cancer Prev Res 4:177~184
Bird RP / 1989 / Aberrant crypts, putative precancerous lesions, in the study of the role of diet in the aetiology of colon cancer / Cancer Surv 8:189~200
Cho Y / 1994 / Crystal structure of a p53 tumor suppressor-DNA complex:Understanding tumorigenic mutations / Science 265:346~355
Dani V / 2007 / Chemopreventive potential of zinc in experimentally induced colon carcinogenesis / Toxicol Lett 171:10~18
Bastide NM / 2011 / Heme Iron from Meat and Risk of Colorectal Cancer: A Meta-analysis and a Review of the Mechanisms Involved / Cancer Prev Res 4:177~184
Bird RP / 1989 / Aberrant crypts, putative precancerous lesions, in the study of the role of diet in the aetiology of colon cancer / Cancer Surv 8:189~200
Cho Y / 1994 / Crystal structure of a p53 tumor suppressor-DNA complex:Understanding tumorigenic mutations / Science 265:346~355
Dani V / 2007 / Chemopreventive potential of zinc in experimentally induced colon carcinogenesis / Toxicol Lett 171:10~18
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