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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 115 - 123 (9page)
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초록· 키워드
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The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory difficulty) attributable to hemodynamically-significant patent ductus arteriosus (hsPDA) at the time of first ibuprofen treatment. In total, 91 infants born from April 2010 to March 2015 were included. Fourteen infants (15.4%) received ibuprofen treatment when there were clinical symptoms due to hsPDA (clinical symptoms group). In clinical symptoms group, infants were younger (25 [23–27] vs. 26 [23–27] weeks; P = 0.012) and lighter (655 [500–930] vs. 880 [370–1,780] grams; P < 0.001). Also, the clinical risk index for babies (CRIB)-II scores were higher and more infants received invasive ventilator care ≤ 2 postnatal days. More infants received multiple courses of ibuprofen in clinical symptoms group. Although the frequency of secondary patent ductus arteriosus (PDA) ligation and the incidence of bronchopulmonary dysplasia (BPD) was higher in the clinical symptoms group in the univariate analysis, after multivariate logistic regression analysis adjusting for the CRIB-II score, birthweight, birth year, and the invasive ventilator care ≤ 2 postnatal days, there were no significant differences in mortality, frequency of secondary ligation and in-hospital outcomes including necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), BPD or death. Our data suggest that we can hold off on PDA treatment until the clinical symptoms become prominent.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Nemerofsky SL / 2008 / The ductus arteriosus rarely requires treatment in infants > 1000 grams / Am J Perinatol 25:661~666
Clyman RI / 2012 / Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? / Semin Perinatol 36:123~129
Heuchan AM / 2014 / Managing the patent ductus arteriosus: current treatment options / Arch Dis Child Fetal Neonatal Ed 99:F431~F436
Evans N / 2015 / Preterm patent ductus arteriosus: a continuing conundrum for the neonatologist? / Semin Fetal Neonatal Med 20:272~277
Clyman RI / 2013 / The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia / Semin Perinatol 37:102~107
Clyman RI / 2012 / Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? / Semin Perinatol 36:123~129
Heuchan AM / 2014 / Managing the patent ductus arteriosus: current treatment options / Arch Dis Child Fetal Neonatal Ed 99:F431~F436
Evans N / 2015 / Preterm patent ductus arteriosus: a continuing conundrum for the neonatologist? / Semin Fetal Neonatal Med 20:272~277
Clyman RI / 2013 / The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia / Semin Perinatol 37:102~107
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