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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 21 - 30 (10page)
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Purpose: Group B streptococcus (GBS) is a causative organism of invasive infections in neonates and pregnant women as well as in non-pregnant adults. Among 10 known serotypes of GBS, uncommon serotypes, such as IV and VI to IX, can cause invasive infections in immunocompromised patients. However, opsonophagocytic antibodies against these serotypes in human sera and intravenous immunoglobulin (IVIG) have not yet been studied. IVIG therapy is used to treat or prevent invasive infections in patients with primary antibody deficiencies. Here, we analyzed the activity of opsonophagocytic antibodies against GBS in IVIG preparations. Methods: Opsonophagocytic antibody activity (opsonic index [OI]) against seven GBS serotypes (II and IV to IX) was evaluated in 16 commercially available IVIG preparations using the opsonophagocytic assay (OPA) in HL-60 cells and baby rabbit complement assay during 2015?2016 in South Korea (UAB GBS OPA, at http://www.vaccine.uab.edu). Results: The estimated serum trough levels of OIs against GBS exceeded the limit of detection (≥4) in all IVIG preparations. For serotype VII, the serum levels of OIs were 6?136, the lowest among all serotypes. An IVIG dose of 400 mg/kg was found to be appropriate for immunocompromised individuals to prevent invasive GBS infections. Conclusions: Most immunoglobulin products displayed high levels of opsonophagocytic activity against GBS, except for serotype VII. IVIG preparations could serve as a therapeutic or immunomodulatory agent for immunocompromised individuals.
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참고문헌 (40)
참고문헌 신청
Phares CR / 2008 / Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005 / JAMA 299:2056~2065
Le Doare K / 2013 / An overview of global GBS epidemiology / Vaccine 31(Suppl 4):D7~D12
Baker CJ / 1976 / Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection / N Engl J Med 294:753~756
Edwards MS / 2012 / Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines / Vaccine 30:4123~4126
Harrison LH / 1995 / Emergence of serotype V group B streptococcal infection among infants and adults / J Infect Dis 171:513
Le Doare K / 2013 / An overview of global GBS epidemiology / Vaccine 31(Suppl 4):D7~D12
Baker CJ / 1976 / Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection / N Engl J Med 294:753~756
Edwards MS / 2012 / Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines / Vaccine 30:4123~4126
Harrison LH / 1995 / Emergence of serotype V group B streptococcal infection among infants and adults / J Infect Dis 171:513
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