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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Transcription regulation by cis-acting elements such as DNA and RNA has not been investigated much compared to that of trans-acting elements like transcription factors because most cis-elements are much larger and more flexible than protein factors. Consequently, it was challenging to recapitulate the function of cis-elements in a reduced system for in vitro assays. However, the recent cryo-electron microscopy (cryo-EM) made it possible to study the effect of nascent RNA elements to the transcription in combination with biochemical experiments as cryo-EM does not require crystallization and tolerates heterogeneity to an extent. In this review, we briefly described the current model on prokaryotic transcriptional pausing based on the crystal and cryo-EM structures of RNA polymerases in different contexts, including an RNA hairpin pause. We then introduced two other nascent RNA elements that modulate transcription ? preQ1 riboswitch and HK022 put RNA. Understanding the function of the RNA elements to transcription will deepen our understanding of the fundamental mechanism transcription and provide the structural basis for drug discovery as well as bioresearch tool development.
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참고문헌 (47)
참고문헌 신청
Artsimovitch, I. / 2000 / Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals / Proc Natl Acad Sci U S A 97:7090~7095
Baker, J. L. / 2012 / Widespread genetic switches and toxicity resistance proteins for fluoride / Science 335:233~235
Banik-Maiti, S. / 1997 / The antiterminator RNA of phage HK022 / J Mol Biol 272:677~687
Barrick, J. E. / 2004 / New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control / Proc Natl Acad Sci U S A 101:6421~6426
Blount, K. F. / 2006 / Riboswitches as antibacterial drug targets / Nat Biotechnol 24:1558~1564
Baker, J. L. / 2012 / Widespread genetic switches and toxicity resistance proteins for fluoride / Science 335:233~235
Banik-Maiti, S. / 1997 / The antiterminator RNA of phage HK022 / J Mol Biol 272:677~687
Barrick, J. E. / 2004 / New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control / Proc Natl Acad Sci U S A 101:6421~6426
Blount, K. F. / 2006 / Riboswitches as antibacterial drug targets / Nat Biotechnol 24:1558~1564
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