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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 30 - 35 (6page)
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Objectives: Although sarcopenia is diagnosed using appendicular lean mass (ALM), only a few long-term studies on changes in both ALM and bone mineral density (BMD) have been reported. The purposes of this study are to evaluate the changes in the parameters of lean mass and bone mass over a 10-year interval and to estimate the effects of osteoporosis pharmacotherapy on muscle. Methods: A total of 175 postmenopausal women were evaluated at baseline and after 10 years for BMD, ALM, fat mass, height, and weight. Subjects were further divided into an osteoporosis treatment group (n ¼ 60) and a control group (n ¼ 67) according to whether they had received pharmacotherapy for > 5 years. This was followed by propensity score matching for age, height, weight, and body mass index (BMI), and estimated parameters were compared between groups. Results: Height, weight, ALM, and fat mass decreased significantly over 10 years (P < 0.05). However, lean mass index (LMI), derived as the ALM divided by the height squared, increased significantly (P < 0.001). BMD increased significantly with osteoporosis treatment (P < 0.05), while no significant differences were observed between the osteoporosis treatment and control groups in the changes to ALM or fat mass. Conclusions: ALM was decreased, while LMI was significantly increased. This contradictory result seems to be affected by age-related height loss. Thus, the effect of height loss needs to be considered when sarcopenia is evaluated longitudinally using LMI.
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참고문헌 (29)
참고문헌 신청
Marty E / 2017 / A review of sarcopenia : enhancing awareness of an increasingly prevalent disease / Bone 105:276~286
Shafiee G / 2017 / Prevalence of sarcopenia in the world : a systematic review and meta-analysis of general population studies / J Diabetes Metab Disord 16:21
Chen LK / 2020 / Asian working group for sarcopenia : 2019 consensus update on sarcopenia diagnosis and treatment / J Am Med Dir Assoc 21:300~307. e2
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : report of the European working group on sarcopenia in older people / Age Ageing 39:412~423
Hirschfeld HP / 2017 / Osteosarcopenia : where bone, muscle, and fat collide / Osteoporos Int 28:2781~2790
Shafiee G / 2017 / Prevalence of sarcopenia in the world : a systematic review and meta-analysis of general population studies / J Diabetes Metab Disord 16:21
Chen LK / 2020 / Asian working group for sarcopenia : 2019 consensus update on sarcopenia diagnosis and treatment / J Am Med Dir Assoc 21:300~307. e2
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : report of the European working group on sarcopenia in older people / Age Ageing 39:412~423
Hirschfeld HP / 2017 / Osteosarcopenia : where bone, muscle, and fat collide / Osteoporos Int 28:2781~2790
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