지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: The purpose of this study was to identify the characteristics of appendicular lean mass (ALM) associated with rheumatoid arthritis (RA) and to analyze appendicular tissue components in patients with RA. Methods: We prospectively reviewed of patients with RA who underwent dual energy X-ray absorptiometry in a single center. From data of 28 patients, ALM was calculated. Regression analysis was used to investigate the association between ALM and RA. Using propensity score matching, patients with RA were compared to the control group from 18,698 patients of Korea National Health and Nutrition Examination Surveys data. RA and control group were matched in a 1: 5, respectively. Results: In regression model, there was significantly negative association between disease activity score and ALM index in patients with RA in unadjusted (β=-0.387, 95% confidence interval [CI], -0.729 to -0.045) and model adjusted for age, sex, and body mass index (β=-0.227, 95% CI, -0.451 to -0.003). In matching with age and sex, the arms fat mass and fat fraction of RA group were significantly lower than that of control group. In matching with age, sex, and body mass index, the ALM index and legs lean mass of RA group were significantly higher than control group. Conclusions: Patients with RA have a lower ALM with higher disease activity. In addition, we found that patients with RA had different tissue component in arms and legs compared to general population.
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참고문헌 (18)
참고문헌 신청
Brown JC / 2016 / Sarcopenia and mortality among a population-based sample of community-dwelling older adults / J Cachexia Sarcopenia Muscle 7:290~298
Morley JE / 2014 / Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014 / J Cachexia Sarcopenia Muscle 5:253~259
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People / Age Ageing 39:412~423
Baker JF / 2014 / Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis / Arthritis Care Res(Hoboken) 66:1612~1618
Giles JT / 2008 / Abnormal body composition phenotypes in older rheumatoid arthritis patients : association with disease characteristics and pharmacotherapies / Arthritis Rheum 59:807~815
Morley JE / 2014 / Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014 / J Cachexia Sarcopenia Muscle 5:253~259
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People / Age Ageing 39:412~423
Baker JF / 2014 / Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis / Arthritis Care Res(Hoboken) 66:1612~1618
Giles JT / 2008 / Abnormal body composition phenotypes in older rheumatoid arthritis patients : association with disease characteristics and pharmacotherapies / Arthritis Rheum 59:807~815
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