Trends in Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy in Korean Carriers of the BRCA1/2 Mutation

정성미; 류재민; 박형석; 박지수; 강은영; 이시윤; 이한별; 윤현조; 유태경; 김지선; 이정언; 한상아; 김동원; 김성원; Korean Hereditary Breast Cancer Study Group

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자료유형: 학술저널

저자정보: 정성미 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University) 류재민 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University) 박형석 (Department of Surgery Yonsei University College of Medicine Seoul Korea) 박지수 (Division of Medical Oncology Department of Internal Medicine Yonsei Cancer Center Yonsei University) 강은영 (Department of Surgery Seoul National University Bundang Hospital Seongnam Korea) 이시윤 (Department of Surgery National Cancer Center Goyang Korea) 이한별 (Department of Surgery Seoul National University College of Medicine Seoul Korea) 윤현조 (Division of Breast Thyroid Surgery Department of Surgery Jeonbuk National University Medical School) 유태경 (Division of Breast Surgery Department of Surgery Seoul St. Mary's Hospital College of Medicine The) 김지선 (Division of Breast Surgery Department of Surgery University of Ulsan College of Medicine Asan Medic) 이정언 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University) 한상아 (Department of Surgery School of Medicine Kyung Hee University Seoul Korea) 김동원 (Department of Surgery Daerim St. Mary's Hospital Seoul Korea) 김성원 (Department of Surgery Daerim St. Mary's Hospital Seoul Korea) Korean Hereditary Breast Cancer Study Group (Korean Hereditary Breast Cancer Study Group)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.6

발행연도: 2020.1

수록면: 647 - 655 (9page)

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Purpose: BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the BRCA1/2 mutation. Methods: We retrospectively reviewed the medical records of BRCA1/2 mutation carriers with (affected carriers) and without (unaffected carriers) breast cancer until August 2018 from 25 Korean Hereditary Breast Cancer (KOHBRA)-affiliated hospitals. Results: The numbers of contralateral risk-reducing mastectomy (RRM) and risk-reducing bilateral salpingo-oophorectomy (RRBSO) in affected carriers have increased 5.8- and 3.6-fold, respectively, since 2013. The numbers of RRBSO in unaffected carriers has increased 8-fold since 2013. The number of institutions that perform RRS has increased gradually. The number of hospitals that perform contralateral RRM on affected carriers increased from 3 in 2012 to 11 in 2018, and that of those that perform RRBSO increased from 7 to 17. The number of hospitals that perform bilateral RRM on unaffected carriers increased from 1 in 2012 to 2 in 2018, and that of those that perform RRBSO increased from 1 to 8. However, the hospitals showed differences in the rates of RRM or RRBSO performed. Conclusion: The incidence of RRS increased each year throughout the study period. However, in Korea, the rate of RRS procedures depended on the hospital.

#Breast neoplasms #Genes #BRCA1 #Genes #BRCA2 #Prophylactic mastectomy #Salpingo-oophorectomy

참고문헌 (26)

참고문헌 신청

Han SA / 2013 / The prevalence of BRCA mutations among familial breast cancer patients in Korea : results of the Korean Hereditary Breast Cancer study / Fam Cancer 12:75~81

구도훈 / 2011 / 한국인BRCA 돌연변이 보인자 여성의 암 발생 감시, 화학적 예방 및 예방적 수술 사용 실태: 단일 기관의 5년간 경험 / Journal of Breast Cancer 14:17~23

Metcalfe K / 2019 / International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation / Br J Cancer 121:15~21

Kuchenbaecker KB / 2017 / Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers / JAMA 317:2402~2416

Han SA / 2011 / The Korean Hereditary Breast Cancer (KOHBRA) study: protocols and interim report / Clin Oncol(R Coll Radiol) 23:434~441

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Sung Mi Jung

소속기관 Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch