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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 280 - 288 (9page)
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Purpose The purpose of this study was to investigate decision patterns to reduce the risks of BRCArelated breast and gynecologic cancers in carriers of BRCA pathogenic variants. We found a change in risk-reducing (RR) management patterns after December 2012, when the National Health Insurance System (NHIS) of Korea began to pay for BRCA testing and riskreducing salpingo-oophorectomy (RRSO) in pathogenic-variant carriers. Materials and Methods The study group consisted of 992 patients, including 705 with breast cancer (BC), 23 with ovarian cancer (OC), 10 with both, and 254 relatives of high-risk patients who underwent BRCA testing at the National Cancer Center of Korea from January 2008 to December 2016.We analyzed patterns of and factors in RR management. Results Of the 992 patients, 220 (22.2%) were carriers of BRCA pathogenic variants. About 92.3% (203/220) had a family history of BC and/or OC, which significantly differed between BRCA1 and BRCA2 carriers (p < 0.001). All 41 male carriers chose surveillance. Of the 179 female carriers, 59 of the 83 carriers (71.1%) with BC and the 39 of 79 unaffected carriers (49.4%) underwent RR management. None of the carriers affected with OC underwent RR management. Of the management types, RRSO had the highest rate (42.5%) of patient choice. The rate of RR surgery was significantly higher after 2013 than before 2013 (46.3% [74/160] vs. 31.6% [6/19], p < 0.001). Conclusion RRSO was the preferred management for carriers of BRCA pathogenic variants. The most important factors in treatment choice were NHIS reimbursement and/or the severity of illness.
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참고문헌 (30)
참고문헌 신청
Claus EB / 1996 / The genetic attributable risk of breast and ovarian cancer / Cancer 77:2318~2324
Easton DF / 1999 / How many more breast cancer predisposition genes are there? / Breast Cancer Res 1:14~17
Beattie MS / 2009 / Uptake, time course, and predictors of risk-reducing surgeries in BRCA carriers / Genet Test Mol Biomarkers 13:51~56
Campeau PM / 2008 / Hereditary breast cancer : new genetic developments, new therapeutic avenues / Hum Genet 124:31~42
Pal T / 2005 / BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases / Cancer 104:2807~2816
Easton DF / 1999 / How many more breast cancer predisposition genes are there? / Breast Cancer Res 1:14~17
Beattie MS / 2009 / Uptake, time course, and predictors of risk-reducing surgeries in BRCA carriers / Genet Test Mol Biomarkers 13:51~56
Campeau PM / 2008 / Hereditary breast cancer : new genetic developments, new therapeutic avenues / Hum Genet 124:31~42
Pal T / 2005 / BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases / Cancer 104:2807~2816
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