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Bioengineering of Virus-like Particles for the Prevention or Treatment of Allergic Diseases
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논문 기본 정보

Type
Academic journal
Author
Pechsrichuang Phornsiri (Center of Excellence in Vaccine Research and Development Faculty of Medicine Chulalongkorn Universi) Namwongnao Supannika (Center of Excellence in Vaccine Research and Development Faculty of Medicine Chulalongkorn Universi) Jacquet Alain (Center of Excellence in Vaccine Research and Development Faculty of Medicine Chulalongkorn Universi)
Journal
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.1 KCI Accredited Journals
Published
2021.1
Pages
23 - 41 (19page)

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Bioengineering of Virus-like Particles for the Prevention or Treatment of Allergic Diseases
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Abstract· Keywords

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Recent findings on the mechanism of allergen-specific immunotherapy (AIT) have revisited the role of immunoglobulin G (IgG) as the development of specific blocking IgG antibodies appeared critical for the successful suppression of T-helper 2 (Th2)-biased allergic responses. Consequently, any form of molecular AIT-promoting potent allergen-specific neutralizing antibodies would be preferred to conventional administration of allergen extracts. The potent immunogenicity of virus-like particles (VLPs) could be harnessed for that purpose. The particle size (20–200 nm) optimizes uptake by antigen-presenting cells as well as lymphatic trafficking. Moreover, the display of antigens in repetitive arrays promotes potent B cell activation for the development of sustained antibody responses. The presentation of self-antigens on the particle surface was even capable to break B cell tolerance. In this review, we describe the immunomodulatory properties of the 3 VLP-based strategies designed so far for the treatment of allergic disease: VLP packaged with CpG motifs as well as chimeric particles displaying pro-Th2/Th2 cytokines or allergens (full-length or B cell epitopes).
#Nanoparticles #allergen #blocking antibodies #CpG motif #autoantibodies

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Hammad H / 2015 / Barrier epithelial cells and the control of type 2 immunity / Immunity 43:29~40 google schola Shamji MH / 2017 / Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers / J Allergy Clin Immunol 140:1485~1498 google schola Valenta R / 2018 / Allergen extracts for in vivo diagnosis and treatment of allergy: is there a future? / J Allergy Clin Immunol Pract 6:1845~1855 google schola Pfaar O / 2018 / Recent developments and highlights in allergen immunotherapy / Allergy 73:2274~2289 google schola Smeekens JM / 2020 / Evolution of immune responses in food immunotherapy / Immunol Allergy Clin North Am 40:87~95 google schola

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