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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 277 - 284 (8page)
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초록· 키워드
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Objective. The purpose of this study was to determine whether the rs7574865 polymorphism of signal transducers and transcription 4 activators (STAT4) in multiple ethnic populations is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. A meta-analysis on the STAT4 T allele rs7574865 polymorphism was performed in all subjects of study as well as in each ethnic population. Results. It included twenty-four manuscripts with 36 comparative studies of 22,898 SLE patients and 24,838 controls. The mean frequency of the STAT4 rs7574865 T allele was 28.5%, ranging from 14.3% to 35.7%, among the controls. T allele rates were 14.3%, 22.8%, 31.9%, 32.4%, and 35.7%, respectively in African American, European, Arab, Asian, and Latin American populations. Meta-analysis revealed a substantial correlation in all subjects between STAT4 rs7574865 and SLE (odds ratio=1.549, 95% confidence interval=1.459∼1.644, p＜0.001). Analysis after stratification of race showed a strong association between the STAT4 rs7574865 T allele and SLE in Europeans, Asians, Latin Americans, African Americans, and Arabs. Conclusion. This meta-analysis demonstrated that the STAT4 rs7574865 polymorphism in different ethnic groups was correlated with SLE susceptibility, and that its prevalence depended on ethnicity.
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참고문헌 (37)
참고문헌 신청
Horvath CM / 2000 / STAT proteins and transcriptional responses to extracellular signals / Trends Biochem Sci 25:496~502
Banchereau J / 2006 / Type I interferon in systemic lupus erythematosus and other autoimmune diseases / Immunity 25:383~392
Korman BD / 2008 / STAT4 : genetics, mechanisms, and implications for autoimmunity / Curr Allergy Asthma Rep 8:398~403
Gupta V / 2018 / Association of ITGAM, TNFSF4, TNFAIP3 and STAT4gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population / Lupus 27:1973~1979
Salmaninejad A / 2017 / Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients / Turk J Pediatr 59:144~149
Banchereau J / 2006 / Type I interferon in systemic lupus erythematosus and other autoimmune diseases / Immunity 25:383~392
Korman BD / 2008 / STAT4 : genetics, mechanisms, and implications for autoimmunity / Curr Allergy Asthma Rep 8:398~403
Gupta V / 2018 / Association of ITGAM, TNFSF4, TNFAIP3 and STAT4gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population / Lupus 27:1973~1979
Salmaninejad A / 2017 / Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients / Turk J Pediatr 59:144~149
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T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
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Leptospirosis as Unusual Trigger of Systemic Lupus Erythematosus
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Factors Associated With Subjective Life Expectancy: Comparison With Actuarial Life Expectancy
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3,3"-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103＋ Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5
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