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논문 기본 정보

자료유형
학술저널
저자정보
Young Ho Lee (Division of Rheumatology Department of Internal Medicine Korea University College of Medicine Seoul) Gwan Gyu Song (Division of Rheumatology Department of Internal Medicine Korea University College of Medicine Seoul)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제27권 제3호
발행연도
2020.1
수록면
152 - 158 (7page)

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Objective. To assess the circulating levels of interleukin (IL)-37 in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and determine a correlation between plasma/serum IL-37 levels and disease activity. Methods. We performed a meta-analysis comparing plasma/serum IL-37 level between patients with RA or SLE and controls, and examined correlation coefficients between circulating IL-37 levels and disease activity. Results. A total of 14 publications included 711 patients with RA and 394 controls, 522 patients with SLE and 259 controls. In the RA group, the IL-37 level was significantly higher than in the control group (standardized mean difference [SMD]=1.222, 95% confidence interval [CI]=0.722∼1.711, p<0.001). Subgroup analysis by sample size showed a significantly higher IL-37 level in RA group of large (n>90) and small sample numbers (n≤90) (SMD=0.994, 95% CI=0.323∼1.666, p<0.001; SMD=1.617, 95% CI=1.328∼1.906, p<0.001). In addition, IL-37 level in SLE group was significantly higher than in control group (SMD=1.096, 95% CI=0.635∼1.558, p<0.001). A strong association between circulating IL-37-level and RA activity based on Disease activity Score 28 was shown (correlation coefficients=0.547, 95% CI=0.355∼0.695, p<0.001). Meta-analysis of the coefficients for correlation indicated a positive correlation between the circulating level of IL-37 and SLE activity based on Systemic Lupus Erythematosus Disease Activity Index (coefficients for correlation<0.588, 95 % CI=0.270∼0.806, p=0.003). Conclusion. Our meta-analysis showed that circulating IL-37 levels are higher in RA and SLE patients, and there is a positive correlation between IL-37 and disease activity in RA and SLE.

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