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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,197 - 1,206 (10page)
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Background Previous investigations reported that the imbalance of intestinal microfora may be the initiation and promotion factor in the pathogenesis of infammatory bowel disease such as ulcerative colitis (UC). Glucocorticoid is a very important class of regulatory molecules in the body. The response of diferent individuals to glucocorticoids can be divided into glucocorticoid sensitive, glucocorticoid resistance and glucocorticoid dependence. Objective We aimed to investigate the diferences in intestinal microfora composition and related metabolic pathways in UC patients with these three diferent glucocorticoid response types. Methods The whole genomic DNA was extracted from fecal specimens. High-throughput sequencing technology was used to analyze the fecal 16S rRNA genome of UC patients with diferent glucocorticoid response types, and functional prediction was performed by PICRUSTs software. Results The results showed that the intestinal microfora of the three groups were mainly composed of Firmicutes, Proteobacteria and Bacteroidetes. Although the species abundance and diversity of intestinal microfora in UC patients difered little among the three groups, the composition of intestinal microfora showed signifcant heterogeneity, which directly led to diferences in the function of intestinal microbiota of UC patients with diferent glucocorticoid responses. Furthermore, of the 240 pathways, “PANTO-PWY: phosphopantothenate biosynthesis I”, “COA-PWY-1: coenzyme A biosynthesis II (mammalian)” and “PWY-4242: pantothenate and coenzyme A biosynthesis III” were signifcantly diferent in the three groups. Conclusions These results indicate that UC patients with diferent glucocorticoids response types have diferent bacterial compositions and functions, which lays a foundation for further study of glucocorticoid resistance in UC patients.
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참고문헌 (51)
참고문헌 신청
Amann RI / 1995 / Phylogenetic identification and in situ detection of individual microbial cells without cultivation / Microbiol Mol Biol Rev 59:143~169
Baba Y / 2017 / Pretreatment of lignocellulosic biomass by cattle rumen fluid for methane production : bacterial flora and enzyme activity analysis / J Biosci Bioeng 123:489~496
Bäckhed F / 2005 / Host-bacterial mutualism in the human intestine / Science 307:1915~1920
Bailey JR / 2017 / Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease / Benef Microbes 8:605~614
Barnes PJ / 2009 / Glucocorticoid resistance in inflammatory diseases / Lancet 373:1905~1917
Baba Y / 2017 / Pretreatment of lignocellulosic biomass by cattle rumen fluid for methane production : bacterial flora and enzyme activity analysis / J Biosci Bioeng 123:489~496
Bäckhed F / 2005 / Host-bacterial mutualism in the human intestine / Science 307:1915~1920
Bailey JR / 2017 / Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease / Benef Microbes 8:605~614
Barnes PJ / 2009 / Glucocorticoid resistance in inflammatory diseases / Lancet 373:1905~1917
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