지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 268 - 274 (7page)
이용수
초록· 키워드
오류제보하기
Background: Graves’ disease (GD) is an autoimmune thyroid disorder caused by antibodies stimulating the thyrotropin (TSH) receptor. TSH receptor antibody (TRAb) measurement is useful for predicting GD relapse after antithyroid drug (ATD) treatment. However, the association of other thyroid autoantibodies with GD relapse remains obscure. Methods: This retrospective study enrolled patients with GD who were initially treated with ATD. TRAb, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured at the initial diagnosis and at the time of ATD discontinuation. Results: A total of 55 patients were enrolled. The mean age was 49.7 years, and 39 patients (70.9%) were female. Antibody positivity at diagnosis was 90.9%, 69.1%, and 61.9% for TRAb, TPOAb, TgAb, respectively. Median ATD treatment period was 15.1months. At the time of ATD withdrawal, TRAb titers decreased uniformly overall. Conversely, TPOAb and TgAb showed variouschanges. After withdrawal of ATD, 19 patients (34.5%) experienced relapse. No clinical features or laboratory results were significantly related to relapse in the overall patient group. However, in the TPOAb positive group at diagnosis, increasing titer of TPOAbor TgAb after ATD treatment was significantly and independently related to relapse free survival (TPOAb: hazard ratio [HR], 17.99;95% confidence interval [CI], 1.66 to 195.43; P=0.02) (TgAb: HR, 5.73; 95% CI, 1.21 to 27.26; P=0.03). Conclusion: Changes in TPOAb or TgAb titers during treatment might be useful for predicting relapse after ATD treatment in patients with positive TPOAb at diagnosis.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Burch HB / 2015 / Management of Graves disease : a review / JAMA 314:2544~2554
Struja T / 2017 / Can we predict relapse in Graves’ disease? Results from a systematic review and meta-analysis / Eur J Endocrinol 176:87~97
Laurberg P / 2006 / Remission of Graves’ disease during anti-thyroid drug therapy. Time to reconsider the mechanism? / Eur J Endocrinol 155:783~786
Guilhem I / 2006 / Differential evolution of thyroid peroxidase and thyrotropin receptor antibodies in Graves’ disease : thyroid peroxidase antibody activity reverts to pretreatment level after carbimazole withdrawal / Thyroid 16:1041~1045
문재훈 / 2013 / The Diagnosis and Management of Hyperthyroidism in Korea: Consensus Report of the Korean Thyroid Association / Endocrinology and Metabolism 28(4):275~279
Struja T / 2017 / Can we predict relapse in Graves’ disease? Results from a systematic review and meta-analysis / Eur J Endocrinol 176:87~97
Laurberg P / 2006 / Remission of Graves’ disease during anti-thyroid drug therapy. Time to reconsider the mechanism? / Eur J Endocrinol 155:783~786
Guilhem I / 2006 / Differential evolution of thyroid peroxidase and thyrotropin receptor antibodies in Graves’ disease : thyroid peroxidase antibody activity reverts to pretreatment level after carbimazole withdrawal / Thyroid 16:1041~1045
문재훈 / 2013 / The Diagnosis and Management of Hyperthyroidism in Korea: Consensus Report of the Korean Thyroid Association / Endocrinology and Metabolism 28(4):275~279
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