지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 15 (15page)
이용수
초록· 키워드
오류제보하기
Background: By estimating the survival rates and exploring prognostic factors in pediatric patients with relapsed or progressed solid tumors, our purpose was to generate background data for future studies. Methods: We reviewed the medical records of 258 patients with solid tumors who experienced relapse/progression and received subsequent salvage treatment between 1996 and 2016. Results: A total of 60 patients remained progression-free during first-line salvage treatment, while the remaining 198 patients experienced relapse/progression again; 149 underwent second-line salvage treatment. A total of 76 patients underwent high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT), and 44 patients received allogeneic SCT. The 10-year progression-free survival (PFS) and overall survival (OS) from relapse/ progression were 18.4% ± 2.7% and 24.5% ± 3.0%, respectively. Survival rates were relatively higher in patients with anaplastic ependymoma, initially non-high-risk neuroblastoma, osteosarcoma, Wilms tumor and retinoblastoma. A multivariate analysis showed that relapse/progression during initial treatment, metastatic relapse/progression, and impossible debulking surgery were independent poor prognostic factors for both PFS and OS. Patients who exhibited a complete response or partial response during conventional salvage treatment showed significantly higher survival after SCT than those with stable disease or progressive disease (10-year OS: 54.8% ± 7.0% vs. 7.0% ± 3.5%, P < 0.001). Conclusion: The prognosis of relapsed/progressed pediatric solid tumors still remains unsatisfactory. New, effective treatment strategies are needed to overcome limitations of current approaches. Hopefully, the background data generated herein will be used in future clinical trials involving patients with relapsed/progressed solid tumors.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Ward E / 2014 / Childhood and adolescent cancer statistics, 2014 / CA Cancer J Clin 64(2):83~103
Shankar AG / 2003 / Outcome after relapse in an unselected cohort of children and adolescents with Ewing sarcoma / Med Pediatr Oncol 40(3):141~147
Hale GA / 2005 / Autologous hematopoietic stem cell transplantation for pediatric solid tumors / Expert Rev Anticancer Ther 5(5):835~846
Perentesis J / 1999 / Autologous stem cell transplantation for high-risk pediatric solid tumors / Bone Marrow Transplant 24(6):609~615
Ceschel S / 2006 / Survival after relapse in children with solid tumors: a follow-up study from the Italian off-therapy registry / Pediatr Blood Cancer 47(5):560~566
Shankar AG / 2003 / Outcome after relapse in an unselected cohort of children and adolescents with Ewing sarcoma / Med Pediatr Oncol 40(3):141~147
Hale GA / 2005 / Autologous hematopoietic stem cell transplantation for pediatric solid tumors / Expert Rev Anticancer Ther 5(5):835~846
Perentesis J / 1999 / Autologous stem cell transplantation for high-risk pediatric solid tumors / Bone Marrow Transplant 24(6):609~615
Ceschel S / 2006 / Survival after relapse in children with solid tumors: a follow-up study from the Italian off-therapy registry / Pediatr Blood Cancer 47(5):560~566
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
An Elevated Platelet Count Increases the Risk of Relapse in Ulcerative Colitis Patients with Mucosal Healing
Gut and Liver
2018 .01
-
Outcome of Intensive Therapy for Children with Relapsed Acute Myeloid Leukemia: A Single Institution Korean Study
Cancer Research and Treatment
2022 .10
-
Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor
Cancer Research and Treatment
2016 .01
-
Salvage treatment of relapsed/refractory LCH
Blood Research
2016 .01
-
Predictors of Relapse in Patients with Organizing Pneumonia
Tuberculosis and Respiratory Diseases
2015 .01
-
Evaluation of prognostic factors in patients with relapsed AML: Clonal evolution versus residual disease
Blood Research
2016 .01
-
Treatment and clinical outcomes of patients relapsing after allogeneic hematopoietic cell transplantation for myelodysplastic syndrome
Blood Research
2018 .01
-
The Value of the Illness-Death Model for Predicting Outcomes in Patients with Non‒Small Cell Lung Cancer
Cancer Research and Treatment
2022 .10
-
Outcomes of limited period of adalimumab treatment in moderate to severe Crohn’s disease patients: Taiwan Society of Inflammatory Bowel Disease Study
Intestinal research
2017 .01
-
Tandem High-dose Chemotherapy without Craniospinal Irradiation in Treatment of Non-metastatic Malignant Brain Tumors in Very Young Children
Journal of Korean Medical Science
2020 .01
-
High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Children with High-Risk or Recurrent Bone and Soft Tissue Sarcomas
Journal of Korean Medical Science
2016 .01
-
Development of a Novel Endoscopic Scoring System to Predict Relapse after Surgery in Intestinal Behçet’s Disease
Gut and Liver
2018 .01
-
Relapse Patterns and Outcomes Following Recurrence of Endometrial Cancer in Northern Thai Women
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Long-term Outcomes after the Discontinuation of Anti-Tumor Necrosis Factor-α Therapy in Patients with Inflammatory Bowel Disease under Clinical Remission: A Korean Association for the Study of Intestinal Disease Multicenter Study
Gut and Liver
2021 .09
-
Treatment for relapsed acute promyelocytic leukemia: what is the best post-remission treatment?
Blood Research
2022 .09
-
Intrachromosomal amplification of chromosome 21 in Korean pediatric patients with B-cell precursor acute lymphoblastic leukemia in a single institution
Blood Research
2017 .01
-
Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse
Cancer Research and Treatment
2022 .07
-
Effects of Less than 60 Days Delay in Surgery on Tumor Progression and Survival Outcomes in Invasive Breast Cancer Patients
Journal of Breast Disease
2016 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0