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자료유형
학술저널
저자정보
정재훈 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.3
발행연도
2021.1
수록면
491 - 499 (9page)

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Graves’ disease is associated with thyrotropin (TSH) receptor stimulating antibody, for which there is no therapeutic agent. This disease is currently treated through inhibition of thyroid hormone synthesis or destruction of the thyroid gland. Recurrence after antithyroid drug (ATD) treatment is common. Recent studies have shown that the longer is the duration of use of ATD, the higher is theremission rate. Considering the relationship between clinical outcomes and iodine intake, recurrence of Graves’ disease is morecommon in iodine-deficient areas than in iodine-sufficient areas. Iodine restriction in an iodine-excessive area does not improve theeffectiveness of ATD or increase remission rates. Recently, Danish and Korean nationwide studies noted significantly higher prevalence of birth defects in newborns exposed to ATD during the first trimester compared to that of those who did not have such exposure. The prevalence of birth defects was lowest when propylthiouracil (PTU) was used and decreased by only 0.15% when methimazole was changed to PTU in the first trimester. Therefore, it is best not to use ATD in the first trimester or to change to PTU beforepregnancy.

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