지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 200 - 206 (7page)
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초록· 키워드
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Purpose: To determine whether continuous antibiotic prophylaxis (CAP) could prevent urinary tract infection (UTI) in mild to moderate antenatal isolated hydronephrosis (IH), characterized by hydronephrosis without ureter and bladder abnormalities, and anteroposterior renal pelvis diameter <16 mm and the Society for Fetal Urology grade <4, in neonatal renal ultrasound. Materials and Methods: Eighty neonates aged 7 to 30 days, with antenatal hydronephrosis and mild to moderate IH on neonatal renal ultrasound, were recruited from August 2015 to December 2016. Neonates were randomly assigned to CAP until hydronephrosis resolution or aged 12 months (CAP group, n=40) or to watchful observation (control group, n=40). The primary outcome was UTI. The probability of UTI was compared between the randomized groups using the Kaplan–Meier method and the log-rank test. Results: Nonadherence occurred in 6/40 parents in the CAP arm (15.0%). Thus, only 34 patients received CAP. UTI occurred in 5/34 patients in the CAP group (14.7%) and in 4/40 controls (10.0%). The probability of UTI was increased in the CAP group (hazard ratio, 1.38; 95% confidence interval, 0.37–5.16; p=0.63). UTI caused by cotrimoxazole resistant bacteria was four times higher in the CAP group than in controls (relative risk, 4.0; 95% confidence interval, 1.2–13.5; p=0.02). The trial was prematurely terminated due to the negative impact of CAP on bacterial sensitivity. Conclusions: The benefits of CAP in infants with mild to moderate IH were inconclusive. CAP conferred a high risk of resistant bacterial organisms when UTI occurs.
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참고문헌 (30)
참고문헌 신청
Nguyen HT / 2014 / Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation(UTD classification system) / J Pediatr Urol 10:982~998
Storm DW / 2018 / Continuous antibiotic prophylaxis in pediatric urology / Urol Clin North Am 45:525~538
Braga LH / 2013 / Antibiotic prophylaxis for urinary tract infections in antenatal hydronephrosis / Pediatrics 131:e251~e261
Alconcher LF / 2012 / Natural history of bilateral mild isolated antenatal hydronephrosis conservatively managed / Pediatr Nephrol 27:1119~1123
Rianthavorn P / 2015 / Diagnostic accuracy of neonatal kidney ultrasound in children having antenatal hydronephrosis without ureter and bladder abnormalities / World J Urol 33:1645~1650
Storm DW / 2018 / Continuous antibiotic prophylaxis in pediatric urology / Urol Clin North Am 45:525~538
Braga LH / 2013 / Antibiotic prophylaxis for urinary tract infections in antenatal hydronephrosis / Pediatrics 131:e251~e261
Alconcher LF / 2012 / Natural history of bilateral mild isolated antenatal hydronephrosis conservatively managed / Pediatr Nephrol 27:1119~1123
Rianthavorn P / 2015 / Diagnostic accuracy of neonatal kidney ultrasound in children having antenatal hydronephrosis without ureter and bladder abnormalities / World J Urol 33:1645~1650
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