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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 108 - 115 (8page)
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초록· 키워드
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Background: The efficacy of combined diuretic treatment in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) is not known. Methods: In a single-center, double-blinded, randomized controlled trial, we randomly assigned 51 adult CAPD patients to receive furosemide 1,000 mg/day, hydrochlorothiazide 100 mg/day, and spironolactone 50 mg/day (triple diuretics [TD] group) or furosemide 1,000 mg/day plus placebo (single diuretic [SD] group) for 6 months. The primary outcome was the difference in daily urine output at the 3rd and 6th month of the study compared to baseline (ΔUO) between the SD and TD group. Secondary outcomes were urinary sodium (UNa) and potassium (UK) excretion and overhydration (OH) measured by bioimpedance at 3 and 6 months compared to baseline (ΔUNa, ΔUK, and ΔOH, respectively) and daily glucose exposure (g/day). Results: Forty-three of 51 patients completed the 6-month trial. The ΔUO at 3 and 6 months was significantly higher in the TD group compared to the SD group (386.32 ± 733.92 mL/day vs. -136.25 ± 629.08 mL/day, P < 0.001, at 3 months; 311.58 ± 640.31 mL/day vs. 120.00 ± 624.07 mL/day, P < 0.001, at 6 months) but there was no significant difference in ΔUNa and ΔUK excretion. Hydration status was significantly better in the TD group (ΔOH 1.84 ± 2.27 L vs. 0.44 ± 1.62 L, P = 0.03, at 3 months; 1.49 ± 2.82 L vs. -0.48 ± 2.61 L, P = 0.02, at 6 months). There was no serious adverse event in this study. Conclusion: For end-stage renal disease patients on CAPD, the combination of furosemide, hydrochlorothiazide, and spironolactone results in higher urine output and better volume control compared to furosemide alone.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Frankenfield DL / 1999 / Trends in clinical indicators of care for adult peritoneal dialysis patients in the United States from 1995 to 1997. ESRD Core Indicators Workgroup / Kidney Int 55:1998~2010
Lameire N / 2004 / Hypervolemia in peritoneal dialysis patients / J Nephrol 17(Suppl 8):S58~S66
Moist LM / 2000 / Predictors of loss of residual renal function among new dialysis patients / J Am Soc Nephrol 11:556~564
Brater DC / 1998 / Diuretic therapy / N Engl J Med 339:387~395
Rastogi SP / 1971 / High dose frusemide in the treatment of hypertension in chronic renal insufficiency and of terminal renal failure / Postgrad Med J 47(Suppl):45~53
Lameire N / 2004 / Hypervolemia in peritoneal dialysis patients / J Nephrol 17(Suppl 8):S58~S66
Moist LM / 2000 / Predictors of loss of residual renal function among new dialysis patients / J Am Soc Nephrol 11:556~564
Brater DC / 1998 / Diuretic therapy / N Engl J Med 339:387~395
Rastogi SP / 1971 / High dose frusemide in the treatment of hypertension in chronic renal insufficiency and of terminal renal failure / Postgrad Med J 47(Suppl):45~53
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