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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 145 - 158 (14page)
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The kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis. Water reabsorption in the CD depends on the action of arginine vasopressin (AVP) and a transepithelial osmotic gradient between the luminal fluid and surrounding interstitium. AVP induces transcellular water reabsorption across CD principal cells through associated signaling pathways after binding to arginine vasopressin receptor 2 (AVPR2). This signaling cascade regulates the water channel protein aquaporin-2 (AQP2). AQP2 is exclusively localized in kidney connecting tubules and CDs. Specifically, AVP stimulates the intracellular translocation of AQP2-containing vesicles to the apical plasma membrane, increasing the osmotic water permeability of CD cells. Moreover, AVP induces transcription of the Aqp2 gene, increasing AQP2 protein abundance. This review provides new insights into the transcriptional regulation of the Aqp2 gene in the kidney CD with an overview of AVP and AQP2. It summarizes current therapeutic approaches for X-linked nephrogenic diabetes insipidus caused by AVPR2 gene mutations.
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참고문헌 (143)
참고문헌 신청
Knepper MA / 2015 / Molecular physiology of water balance / N Engl J Med 372:1349~1358
Choi HJ / 2012 / Patterns of gene and metabolite define the effects of extracellular osmolality on kidney collecting duct / J Proteome Res 11:3816~3828
Hwang GS / 2010 / Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by(1)H-NMR-based metabonomics / Am J Physiol Renal Physiol 298:F461~F470
Schnermann J / 1998 / Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice / Proc Natl Acad Sci U S A 95:9660~9664
Nielsen S / 1993 / CHIP28 water channels are localized in constitutively water-permeable segments of the nephron / J Cell Biol 120:371~383
Choi HJ / 2012 / Patterns of gene and metabolite define the effects of extracellular osmolality on kidney collecting duct / J Proteome Res 11:3816~3828
Hwang GS / 2010 / Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by(1)H-NMR-based metabonomics / Am J Physiol Renal Physiol 298:F461~F470
Schnermann J / 1998 / Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice / Proc Natl Acad Sci U S A 95:9660~9664
Nielsen S / 1993 / CHIP28 water channels are localized in constitutively water-permeable segments of the nephron / J Cell Biol 120:371~383
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