지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Andersen K / 1999 / Gender differences in the incidence of AD and vascular dementia: the EURODEM Studies. EURODEM Incidence Research Group / Neurology 53:1992~1997
Bachman DL / 1992 / Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study / Neurology 42:115~119
Ruitenberg A / 2001 / Incidence of dementia: does gender make a difference? / Neurobiol Aging 22:575~580
Barnes LL / 2005 / Sex differences in the clinical manifestations of Alzheimer disease pathology / Arch Gen Psychiatry 62:685~691
Sinforiani E / 2010 / Impact of gender differences on the outcome of Alzheimer’s disease / Dement Geriatr Cogn Disord 30:147~154
Bachman DL / 1992 / Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study / Neurology 42:115~119
Ruitenberg A / 2001 / Incidence of dementia: does gender make a difference? / Neurobiol Aging 22:575~580
Barnes LL / 2005 / Sex differences in the clinical manifestations of Alzheimer disease pathology / Arch Gen Psychiatry 62:685~691
Sinforiani E / 2010 / Impact of gender differences on the outcome of Alzheimer’s disease / Dement Geriatr Cogn Disord 30:147~154
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