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논문 기본 정보

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학술저널
저자정보
Yosuke Shimodaira (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Kengo Onochi (Division of Gastroenterology Omagari Kosei Medical Center) Kenta Watanabe (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) So Takahashi (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Sho Fukuda (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Noboru Watanabe (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Shigeto Koizumi (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Tamotsu Matsuhashi (Department of Gastroenterology and Neurology Akita University Graduate School of Medicine) Katsunori Iijima (Akita University Graduate School of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.2
발행연도
2021.1
수록면
225 - 231 (7page)

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Background/Aims: 5-Aminosalicylic acid (5-ASA) is a basic drug for inducing and maintaining remission for ulcerative colitis. One of its formulations has a coating with a pH-dependent degradation that ensures the release 5-ASA at the terminal ileum. No evidence has been shown concerning the effects of proton pump inhibitors (PPIs) or H<sub>2</sub> receptor antagonists (H2RAs) on the clinical course of ulcerative colitis patients in remission. The present study assessed the effect of PPIs or H2RAs on the relapse of ulcerative colitis patients in clinical remission maintained by pH-dependent released 5-ASA.Methods: Ulcerative colitis patients who had been prescribed time- or pH-dependent-released 5-ASA between January 2015 and December 2018 were enrolled in this multicenter retrospective study. The period of remission until relapse occurred was analyzed among the patients taking time-dependent-released 5-ASA or pH-dependent-released 5-ASA with/without PPIs or H2RAs.Results: One hundred and nineteen patients were analyzed in this study. In the primary endpoint, the relapse rate was higher in patients taking pH-dependent-released 5-ASA and PPIs or H2RAs than in those taking the pH-dependent-released 5-ASA without PPIs or H2RAs, while the relapse rate was similar in patients taking the time-dependent-released 5-ASA with or without PPIs or H2RAs concomitantly. Patients with a short duration of disease and middle-aged patients more frequently showed relapse with PPIs or H2RAs than the other patients.Conclusions: The coadministration of PPIs or H2RAs affects the clinical course of ulcerative colitis in remission maintained by pH-dependent-released 5-ASA.
#5-Aminosalicylic acid #Proton pump inhibitors #H2 receptor antagonists

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참고문헌 (20)

참고문헌 신청
Kaplan GG / 2017 / Understanding and preventing the global increase of inflammatory bowel disease / Gastroenterology 152:313~321 google schola Jeong DY / 2019 / Induction and maintenance treatment of inflammatory bowel disease : a comprehensive review / Autoimmun Rev 18:439~454 google schola Ungaro R / 2017 / Ulcerative colitis / Lancet 389:1756~1770 google schola Burger D / 2011 / Conventional medical management of inflammatory bowel disease / Gastroenterology 140:1827~1837 google schola Irvine EJ / 2008 / The effect of mesalazine therapy on quality of life in patients with mildly and moderately active ulcerative colitis / Aliment Pharmacol Ther 28:1278~1286 google schola

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