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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 조선대학교 의학연구원 Medical Biological Science and Engineering Medical Biological Science and Engineering Vol.3 No.2
- 발행연도
- 2020.1
- 수록면
- 31 - 35 (5page)
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초록· 키워드
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Over the past few decades, certain coronaviruses have become threat to humans. Coronaviruses such as severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV) have caused lethal outbreaks in 2003 and 2012, respectively. In 2019, severe infectious coronavirus outbreak with unusual pneumonia was reported in Wuhan, China, which later became pandemic. Due to the similarity of coronavirus disease 2019 (COVID-19) to SARS-CoV, the virus was termed as SARS-CoV-2. Although viral proteases such as papain-like 2 protease (PL2Pro) are essential for virulence of SARS-CoV, limited information is available on the role of protease in viral pathogenesis. This article highlights the significance of ubiquitination in signal transduction for innate immune responses and the importance of deubiquitinase activity of PL2Pro in inhibiting host antiviral activities.
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참고문헌 (22)
참고문헌 신청
Tang B / 2020 / An updated estimation of the risk of transmission of the novel coronavirus(2019-nCov) / Infect Dis Model 5:248~255
Gallagher TM / 2001 / Coronavirus spike proteins in viral entry and pathogenesis / Virology 279:371~374
Schoeman D / 2019 / Coronavirus envelope protein : current knowledge / Virol J 16:69
Gralinski LE / 2020 / Return of the coronavirus : 2019-nCoV / Viruses 12:135
Cyranoski D / 2020 / Did pangolins spread the China coronavirus to people? / Nature
Gallagher TM / 2001 / Coronavirus spike proteins in viral entry and pathogenesis / Virology 279:371~374
Schoeman D / 2019 / Coronavirus envelope protein : current knowledge / Virol J 16:69
Gralinski LE / 2020 / Return of the coronavirus : 2019-nCoV / Viruses 12:135
Cyranoski D / 2020 / Did pangolins spread the China coronavirus to people? / Nature
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