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논문 기본 정보

자료유형
학술저널
저자정보
Bruna Barbosa da Luz (Department of Pharmacology Federal University of Paraná (UFPR)) Natalia Mulinari Turin de Oliveira (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Isabella Wzorek França dos Santos (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Luana Zampieron Paza (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Lara Luisa Valerio de Mello Braga (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Fernanda da Silva Platner (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Maria Fernanda de Paula Werner (Department of Pharmacology Federal University of Paraná (UFPR)) Elizabeth Soares Fernandes (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College) Daniele Maria-Ferreira (Pelé Pequeno Príncipe Research Institute Pequeno Príncipe College)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.4
발행연도
2021.10
수록면
379 - 385 (7page)
DOI
10.5217/ir.2020.00087

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In late 2019, an outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated in Wuhan, Hubei province, China. The major clinical symptoms described for coronavirus disease (COVID-19) include respiratory distress and pneumonia in severe cases, and some patients may experience gastrointestinal impairments. In accordance, viral RNA or live infectious virus have been detected in feces of patients with COVID-19. Binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) is a vital pathway for the virus entry into human cells, including those of the respiratory mucosa, esophageal epithelium as well as the absorptive enterocytes from ileum and colon. The interaction between SARS-CoV-2 and ACE2 receptor may decrease the receptor expression and disrupt the function of B0AT1 transporter influencing the diarrhea observed in COVID-19 patients. In this context, a fecal-oral transmission route has been considered and points out a role for the digestive tract in disease transmission and severity. Here, in order to further understand the impact of COVID-19 in human physiology, the cellular and molecular mechanisms of SARS-CoV-2 infection and disease severity are discussed in the context of gastrointestinal disturbances.

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