지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 81 - 96 (16page)
이용수
초록· 키워드
오류제보하기
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects 1–2% of people by the age of 70 years. Age isthe most important risk factor, and most cases are sporadic without any known environmental or genetic causes. Since the late1990s, mutations in the genes SNCA, PRKN, LRRK2, PINK1, DJ-1, VPS35, and GBA have been shown to be important risk factorsfor PD. In addition, common variants with small effect sizes are now recognized to modulate the risk for PD. Most studiesin genetic PD have focused on finding new genes, but few have studied the long-term outcome of patients with the specific geneticPD forms. Patients with known genetic PD have now been followed for more than 20 years, and we see that they may havedistinct and different prognoses. New therapeutic possibilities are emerging based on the genetic cause underlying the disease. Future medication may be based on the pathophysiology individualized to the patient’s genetic background. The challenge is tofind the biological consequences of different genetic variants. In this review, the clinical patterns and long-term prognoses of themost common genetic PD variants are presented.
목차
등록된 정보가 없습니다.
참고문헌 (163)
참고문헌 신청
Polymeropoulos MH / 1997 / Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease / Science 276:2045~2047
Spillantini MG / 1997 / Alpha-synuclein in Lewy bodies / Nature 388:839~840
Kitada T / 1998 / Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism / Nature 392:605~608
Valente EM / 2001 / Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36 / Am J Hum Genet 68:895~900
Bonifati V / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
Spillantini MG / 1997 / Alpha-synuclein in Lewy bodies / Nature 388:839~840
Kitada T / 1998 / Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism / Nature 392:605~608
Valente EM / 2001 / Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36 / Am J Hum Genet 68:895~900
Bonifati V / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Changes in Epidemiological Trends and Rehabilitation Usage in Neurological Diseases in Korea: Parkinson's Disease
뇌신경재활
2021 .01
-
Genetic quality control of laboratory animal
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Genetic Profiles of Korean Patients With Glucose-6-Phosphate Dehydrogenase Deficiency
Annals of Laboratory Medicine
2017 .01
-
Peripheral Blood Immune Cell-based Biomarkers in Anti-PD-1/PD-L1 Therapy
Immune Network
2020 .02
-
Genetic monitoring of laboratory animal
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Cancer Research and Treatment
2017 .01
-
Dysphagia Requiring Medical Attention in Parkinson’s Disease: A Korean Population-Based Study
Journal of Korean Medical Science
2023 .04
-
Navigating the landscape of clinical genetic testing: insights and challenges in rare disease diagnostics
Childhood Kidney Diseases
2024 .02
-
The Frequency of Korean Patients With Parkinson’s Disease Carrying GBA Mutations in a Subgroup With Age at Onset ≤ 55 Years Old
Journal Of Movement Disorders
2023 .05
-
Clinical Implication of High Sensitivity C-Reactive Protein for the Development of Dementia in Parkinson’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination
Journal Of Movement Disorders
2021 .09
-
Disease Prediction with Large-Scale Genetic Data
대한임상종양학회 학술대회지
2018 .02
-
PD-L1 Expression and Combined Status of PD-L1/PD-1–Positive Tumor Infiltrating Mononuclear Cell Density Predict Prognosis in Glioblastoma Patients
Journal of Pathology and Translational Medicine
2017 .01
-
파킨슨병에 대한 젊은 성인과 노인의 인식 비교
한국신경근육재활학회지
2021 .08
-
파킨슨병 연하장애의 임상양상과 평가
대한연하장애학회지
2024 .01
-
Update on Parkinson’s Disease Rehabilitation
뇌신경재활
2022 .07
-
COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson’s Disease Patient Care
Journal Of Movement Disorders
2020 .01
-
Advantages of robotic PD over laparoscopic PD
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis
PSYCHIATRY INVESTIGATION
2015 .01
-
Natural Products as Potential Therapeutic Strategies for Parkinson"s Disease
대한의생명과학회지
2023 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0