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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 182 - 189 (8page)
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초록· 키워드
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Purpose: There are few reports from Asian countries about the long-term results of aromatase inhibitor adjuvant treatment for breast cancer. This observational study aimed to evaluate the long-term effects of letrozole in postmenopausal Korean women with operable breast cancer. Methods: Self-reported quality of life (QoL) scores were serially assessed for 3 years during adjuvant letrozole treatment using the Korean version of the Functional Assessment of Cancer Therapy-Breast questionnaires (version 3). Changes in bone mineral density (BMD) and serum cholesterol levels were also examined. Results: All 897 patients received the documented informed consent form and completed a baseline questionnaire before treatment. Adjuvant chemotherapy was administered to 684 (76.3%) subjects, and 410 (45.7%) and 396 (44.1%) patients had stage I and II breast cancer, respectively. Each patient completed questionnaires at 3, 6, 12, 18, 24, 30, and 36 months after enrollment. Of 897 patients, 749 (83.5%) completed the study. The dropout rate was 16.5%. The serial trial outcome index, the sum of the physical and functional wellbeing subscales, increased gradually and significantly from baseline during letrozole treatment (p<0.001). The mean serum cholesterol level increased significantly from 199 to 205 after 36 months (p=0.042). The mean BMD significantly decreased from –0.39 at baseline to –0.87 after 36 months (p<0.001). Conclusion: QoL gradually improved during letrozole treatment. BMD and serum cholesterol level changes were similar to those in Western countries, indicating that adjuvant letrozole treatment is well tolerated in Korean women, with minimal ethnic variation.
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참고문헌 (24)
참고문헌 신청
박은화 / 2017 / Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress / Journal of Breast Cancer 20(1):1~11
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Howell A / 2005 / Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer / Lancet 365:60~62
Coombes RC / 2004 / A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer / N Engl J Med 350:1081~1092
BIG 1-98 Collaborative Group / 2009 / Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer / N Engl J Med 361:766~776
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Howell A / 2005 / Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer / Lancet 365:60~62
Coombes RC / 2004 / A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer / N Engl J Med 350:1081~1092
BIG 1-98 Collaborative Group / 2009 / Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer / N Engl J Med 361:766~776
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