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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 157 - 160 (4page)
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초록· 키워드
오류제보하기
Genes related to serotonin are associated with responses to treatment for depression. We examined associations between the serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes and responses to treatment for depressive disorders in acute coronary syndrome (ACS). A total of 255 patients who met the DSM-IV major or minor depressive disorder and recently developed ACS were randomly assigned to the escitalopram (n=127) or placebo (n=128) group in this 24-week double-blind trial (ClinicalTrial.gov identifier: NCT00419471). Remission was defined as a Hamilton Rating Scale for Depression (HAMD) score ≤7. Assays were performed for the 5-HTTLPR, STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G genotypes. Escitalopram was superior to placebo for treating depressive disorder with ACS but there were no significant associations between serotonergic genes and treatment responses even when considering ACS severity. The effect of escitalopram was independent of 5-HTT and 5-HTR2a polymorphisms.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Rudisch B / 2003 / Epidemiology of comorbid coronary artery disease and depression / Biol Psychiatry 54:227~240
Baumeister H / 2011 / Psychological and pharmacological interventions for depression in patients with coronary artery disease / Cochrane Database Syst Rev 9:CD008012
Maier W / 2008 / Contribution of allelic variations to the phenotype of response to antidepressants and antipsychotics / Eur Arch Psychiatry Clin Neurosci 258(Suppl 1):12~20
Kato M / 2010 / Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder / Mol Psychiatry 15:473~500
Kim JM / 2015 / Escitalopram treatment for depressive patients with acute coronary syndrome : a 24 week double-blind placebo-controlled trial / J Clin Psychiatry 76:62~68
Baumeister H / 2011 / Psychological and pharmacological interventions for depression in patients with coronary artery disease / Cochrane Database Syst Rev 9:CD008012
Maier W / 2008 / Contribution of allelic variations to the phenotype of response to antidepressants and antipsychotics / Eur Arch Psychiatry Clin Neurosci 258(Suppl 1):12~20
Kato M / 2010 / Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder / Mol Psychiatry 15:473~500
Kim JM / 2015 / Escitalopram treatment for depressive patients with acute coronary syndrome : a 24 week double-blind placebo-controlled trial / J Clin Psychiatry 76:62~68
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