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논문 기본 정보

자료유형
학술저널
저자정보
Xinyu Wan (Shanghai Jiao Tong University School of Medicine Shanghai China) Xiaomin Yang (Shanghai Jiao Tong University School of Medicine Shanghai China) Fan Yang (Shanghai Jiao Tong University School of Medicine Shanghai China) Tianyi Wang (Shanghai Jiao Tong University School of Medicine Shanghai China) Lixia Ding (Shanghai Jiao Tong University School of Medicine Shanghai China) Lili Song (Shanghai Jiao Tong University School of Medicine Shanghai China) Yan Miao (Shanghai Jiao Tong University School of Medicine Shanghai China) Xiang Wang (Shanghai Jiao Tong University School of Medicine Shanghai China) Yani Ma (Shanghai Jiao Tong University School of Medicine Shanghai China) Chengjuan Luo (Shanghai Jiao Tong University School of Medicine Shanghai China) Jingyan Tang (Shanghai Jiao Tong University School of Medicine Shanghai China) Longjun Gu (Shanghai Jiao Tong University School of Medicine Shanghai China) Jing Chen (Shanghai Jiao Tong University School of Medicine Shanghai China) Yanjing Tang (Shanghai Jiao Tong University School of Medicine Shanghai China) Jun Lu (Children’s Hospital of Soochow University Jiangsu China) Benshang Li (Shanghai Jiao Tong University School of Medicine Shanghai China)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제3호
발행연도
2022.7
수록면
917 - 925 (9page)
DOI
10.4143/crt.2021.399

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PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.
#B-ALL #Extramedullary relapse #CD19 CAR-T #Second CAR-T

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