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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 10 (10page)
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Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3–31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P = 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.
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참고문헌 (27)
참고문헌 신청
Leibovich BC / 2010 / Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma / J Urol 183(4):1309~1315
Moch H / 2000 / Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors / Cancer 89(3):604~614
Janzen NK / 2003 / Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease / Urol Clin North Am 30(4):843~852
Hollingsworth JM / 2006 / Rising incidence of small renal masses: a need to reassess treatment effect / J Natl Cancer Inst 98(18):1331~1334
Randall JM / 2014 / Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art / Cancer Metastasis Rev 33(4):1109~1124
Moch H / 2000 / Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors / Cancer 89(3):604~614
Janzen NK / 2003 / Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease / Urol Clin North Am 30(4):843~852
Hollingsworth JM / 2006 / Rising incidence of small renal masses: a need to reassess treatment effect / J Natl Cancer Inst 98(18):1331~1334
Randall JM / 2014 / Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art / Cancer Metastasis Rev 33(4):1109~1124
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