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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 386 - 395 (10page)
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초록· 키워드
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Background: Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes. Methods: The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m²) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined. Results: There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin. Conclusion: Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Pedersen BK / 2013 / Muscle as a secretory organ / Compr Physiol 3:1337~1362
Moon SS / 2014 / Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010 / Endocr J 61:61~70
Lee CG / 2011 / Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus / J Am Geriatr Soc 59:1217~1224
Bostrom P / 2012 / A PGC1-α-dependent myokine that drives brownfat-like development of white fat and thermogenesis / Nature 481:463~468
Elsen M / 2014 / Browning of white fat: does irisin play a role in humans? / J Endocrinol 222:R25~R38
Moon SS / 2014 / Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010 / Endocr J 61:61~70
Lee CG / 2011 / Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus / J Am Geriatr Soc 59:1217~1224
Bostrom P / 2012 / A PGC1-α-dependent myokine that drives brownfat-like development of white fat and thermogenesis / Nature 481:463~468
Elsen M / 2014 / Browning of white fat: does irisin play a role in humans? / J Endocrinol 222:R25~R38
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