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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 89 - 95 (7page)
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Obesity has quickly become a worldwide pandemic, causing major adverse health outcomes such as dyslipidemia, type 2 diabetes mellitus, cardiovascular disease and cancers. Obesity-induced insulin resistance is the key for developing these metabolic disorders, and investigation to understand the molecular mechanisms involved has been vibrant for the past few decades. Of these, low-grade chronic inflammation is suggested as a critical concept in the development of obesity-induced insulin resistance, and the anti-inflammatory effect of nitric oxide (NO) signaling has been reported to be linked to improvement of insulin resistance in multiple organs involved in glucose metabolism. Recently, a body of evidence suggested that vasodilatory-stimulated phosphoprotein (VASP), a downstream mediator of NO signaling plays a crucial role in the anti-inflammatory effect and improvement of peripheral insulin resistance. These preclinical studies suggest that NO/VASP signaling could be an ideal therapeutic target in the treatment of obesity-related metabolic dysfunction. In this review, we introduce studies that investigated the protective role of NO/VASP signaling against obesity-related inflammation and insulin resistance in various tissues.
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참고문헌 (45)
참고문헌 신청
Korean Diabetes Association / 2015 / Korean Diabetes Fact Sheet 2015 / Korean Diabetes Association :1~28
Hotamisligil GS / 1993 / Adipose expression of tumor necrosis factor-alpha: direct role in obesitylinked insulin resistance / Science 259:87~91
Rocha VZ / 2009 / Obesity, inflammation, and atherosclerosis / Nat Rev Cardiol 6:399~409
McArdle MA / 2013 / Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies / Front Endocrinol (Lausanne) 4:52
Sansbury BE / 2014 / Regulation of obesity and insulin resistance by nitric oxide / Free Radic Biol Med 73:383~399
Hotamisligil GS / 1993 / Adipose expression of tumor necrosis factor-alpha: direct role in obesitylinked insulin resistance / Science 259:87~91
Rocha VZ / 2009 / Obesity, inflammation, and atherosclerosis / Nat Rev Cardiol 6:399~409
McArdle MA / 2013 / Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies / Front Endocrinol (Lausanne) 4:52
Sansbury BE / 2014 / Regulation of obesity and insulin resistance by nitric oxide / Free Radic Biol Med 73:383~399
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