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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 222 - 225 (4page)
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초록· 키워드
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Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days. The tumor had a high proliferation rate (mitotic count > 50/10 HPFs and 90% of the Ki-67 index) and lymph-node metastases had occurred. On immunohistochemistry, the tumor cells expressed CD56 and synaptophysin. Large-cell NEC was confirmed. Systemic chemotherapy with cisplatin/etoposide was done. The patient is still alive after 3 years with no evidence of recurrence.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Ilett EE / 2015 / Neuroendocrine carcinomas of the gastroenteropancreatic system: a comprehensive review / Diagnostics (Basel) 5:119~176
Sorbye H / 2013 / Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study / Ann Oncol 24:152~160
Yamaguchi T / 2014 / Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system / Cancer Sci 105:1176~1181
Bernick PE / 2004 / Neuroendocrine carcinomas of the colon and rectum / Dis Colon Rectum 47:163~169
Patta A / 2011 / First-line cisplatin plus etoposide in high-grade metastatic neuroendocrine tumors of colon and rectum (MCRC NET): review of 8 cases / Anticancer Res 31:975~978
Sorbye H / 2013 / Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study / Ann Oncol 24:152~160
Yamaguchi T / 2014 / Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system / Cancer Sci 105:1176~1181
Bernick PE / 2004 / Neuroendocrine carcinomas of the colon and rectum / Dis Colon Rectum 47:163~169
Patta A / 2011 / First-line cisplatin plus etoposide in high-grade metastatic neuroendocrine tumors of colon and rectum (MCRC NET): review of 8 cases / Anticancer Res 31:975~978
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