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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.69 No.2
- 발행연도
- 2016.1
- 수록면
- 181 - 184 (4page)
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초록· 키워드
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Sodium nitroprusside (SNP) is an anti-hypertensive drug, commonly used to decrease the systemic vascular resistance and lower the blood pressure. When the amount of cyanide generated by the SNP exceeds the metabolic capacity for detoxification, cyanide toxicity occurs. Under general anesthesia and cardiopulmonary bypass (CPB), it may be difficult to detect the development of cyanide toxicity. In cardiac surgical patients, hemolysis, hypothermia and decreased organ perfusion, which emphasize the risk of cyanide toxicity, may develop as a consequence of CPB. In particular, hemolysis during CPB may cause an unexpected overproduction of cyanide due to free hemoglobin release. We experienced a patient who demonstrated SNP tachyphylaxis and cyanide toxicity during CPB, even though the total amount of SNP administered was much lower than the recommended dose. We therefore report this case with a review of the relevant literature.
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참고문헌 (14)
참고문헌 신청
Thomas C / 2009 / Sodium-nitroprusside-induced cyanide toxicity in pediatric patients / Expert Opin Drug Saf 8:599~602
López-Herce J / 2005 / Elevated carboxyhemoglobin associated with sodium nitroprusside treatment / Intensive Care Med 31:1235~1238
Patel CB / 1986 / Use of sodium nitroprusside in post-coronary bypass surgery. A plea for conservatism / Chest 89:663~667
Smith RP / 1974 / Nitroprusside produces cyanide poisoning via reaction with hemoglobin / J Pharmacol Exp Ther 191:557~563
Morocco AP / 2005 / Cyanides / Crit Care Clin 21:691~705
López-Herce J / 2005 / Elevated carboxyhemoglobin associated with sodium nitroprusside treatment / Intensive Care Med 31:1235~1238
Patel CB / 1986 / Use of sodium nitroprusside in post-coronary bypass surgery. A plea for conservatism / Chest 89:663~667
Smith RP / 1974 / Nitroprusside produces cyanide poisoning via reaction with hemoglobin / J Pharmacol Exp Ther 191:557~563
Morocco AP / 2005 / Cyanides / Crit Care Clin 21:691~705
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